Secretory Phospholipase A_2(Diversity of Phospholipase A_2 Enzymes)

概要

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Secretory phospholipase A_2 (sPLA_2) is a growing family of structurally related, disulfide-rich, low molecular weight, lipolytic enzymes with a His-Asp catalytic dyad. sPLA_2s are distributed in a wide variety of vertebrate and invertebrate animals, plants, bacteria, and viruses, and there are 10 catalytically active sPLA_2 isozymes in mammals. Although the structural bases for mammalian sPLA_2s have been well documented, their physiological functions are still subject to debate. Individual mammalian sPLA_2s have distinct enzymatic properties and display distinct tissue expression patterns, suggesting that each enzyme acts on distinct phospholipid membrane moieties in vivo. In this article, we briefly review our latest understanding of the possible physiological functions of sPLA_2s, in keeping with their diverse actions on mammalian and nonmammalian cell membranes.
公益社団法人日本薬学会の論文
2004-08-01