Chemical Tools for Targeted Mutagenesis of DNA Based on Triple Helix Formation (Biological and Pharmaceutical Aspects of Nucleic Acids Chemistry)

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概要

• 論文の詳細を見る

• The development of methods for targeted mutagenesis shows promise as an alternative form of gene therapy. Triple helix-forming oligonucleotides (TFOs) provide an attractive strategy for inducing mutations. Especially, alkylation of nucleobases with functionalized TFOs would have potential for site-directed mutation. Several studies have demonstrated that treatment of mammalian cells with TFOs can be exploited to introduce desired sequence changes and point mutations. This review summarizes targeted mutagenesis using reactive TFOs, including studies with photo reactive psolaren derivatives as well as a new reactive derivative recently developed by our group.

• 公益社団法人日本薬学会の論文
• 2004-04-01

著者

• 佐々木 茂樹

  九州大学

• 佐々木 茂貴

  九州大学

• Sasaki Shigeki

  Faculty of Pharmaceutical Sciences, Kyushu University

• SASAKI Shigeki

  Graduate School of Pharmaceutical Sciences, Kyushu University

• 佐々木 茂貴

  九州大学大学院薬学研究院

• Sasaki Shigeki

  Graduate School Of Pharmaceutical Sciences Kyushu University

• 佐々木 茂貴

  九州大学薬学部

• Nagatsugi F

  Graduate School Of Pharmaceutical Sciences Kyushu University:crest Japan Science And Technology Agen

• 佐々木 茂貴

  九州大学薬学部製薬化学科

• Nagatsugi Fumi

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Sasaki Shigeki

  Graduate School Of Pharmaceutical Sciences Kyushu University:crest Japan Science And Technology Agen

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