Studies on Compounds Related to Antitumor Agents. Syntheses of 8-Substituted N^6,N^6-Dimethyladenosine Derivatives
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概要
- 論文の詳細を見る
N^6,N^6-Dimethyl-8-methylsulfonyladenosine, obtained from N^6,N^6-dimethyl-8-methylthioadenosine by highly selective oxidation with KMnO_4,was treated with cyanide ion to give 8-cyano-N^6,N^6-dimethyladenosine. The conversion of the cyano group to methyl imidate, methoxycarbonyl, carbamoyl, carbothioamide, and carboxylic acid moieties was achieved. These 8-substituted N^6,N^6-dimethyladenosines may possess resonances structures involving positions 6 and 8 in adenosine, as indicated by the spectroscopic data. They showed no antitumor activity.
- 公益社団法人日本薬学会の論文
- 1986-09-25
著者
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加藤 哲夫
株式会社アラクス研究開発部
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加藤 哲夫
Research and Development Division, General Laboratory, Arakawa Chotaro & Co.,
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荒川 永太郎
Research and Development Division, General Laboratory, Arakawa Chotaro & Co.,
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小川 秀一
Research and Development Division, General Laboratory, Arakawa Chotaro & Co.,
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鈴村 恭子
Laboratory of Chemotherapy, Aichi Cancer Center Research Institute
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加藤 武俊
Laboratory of Chemotherapy, Aichi Cancer Center Research Institute
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小川 秀一
Research And Development Division General Laboratory Arakawa Chotaro & Co.
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加藤 武俊
Laboratory Of Chemotherapy Aichi Cancer Center Research Institute
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鈴村 恭子
Laboratory Of Chemotherapy Aichi Cancer Center Research Institute
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荒川 永太郎
Research And Development Division General Laboratory Arakawa Chotaro & Co.
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