Effect of Fasting on Body Fluids and Intestinal Drug Absorption in Rats

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The present work was designed to make clear a mechanism of fasting-induced reduction in the in situ intestinal absorption of sulfanilamide. Physiological characteristics of fasting in rats were investigated with attention to homeostatic fluid transfer within body. An increase in arterial hematocrit was found to be in proportion to the duration of fasting, which indicates unphysiological conditions in internal fluid environment of body. The method was consisted of intensive monitorings of both the ratio in the transmucosal fluid movement and the arterial hematocrit of the subjected animals during the course of the intestinal perfusion experiments. There observed significant depressions in the transmucosal fluid movement and also in the fluid transfer across the capillary wall in 60-hour-fasted rats as compared with non-fasted controls. These results suggest that fasting induced a fall in both the rate and extent of water exchange between fluid compartments in body, and secondary resulted in the depression of intestinal sulfanilamide absorption.
公益社団法人日本薬学会の論文
1977-02-25