Effects of Tonicities and Solutes of Solutions on the Lethality and the Survival Time after Intraduodenal Administration of Ephedrine Hydrochloride in Mice

概要

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Attempts confirming the effect of the transmucosal fluid movement and the glucose effect on the intestinal drug absorption, those of which had been revealed in the previous studies of in situ experiment, in the in vivo studies were undertaken using an intraduodenal administration method to mice. These effects were reflected amply on the indices of the lethality and the survival time after the administration of ephedrine hydrochloride. From the results obtained in the present study, it was able to be concluded that the effects of the transmucosal fluid movement and the glucose are observed realistically in the in vivo experiment. In the course of the studies, calcium chloride was appeared to affect similar in nature to the glucose effect on the drug absorption from the small intestine.
公益社団法人日本薬学会の論文
1975-09-25