Chemical Modification of Lactose. XI. A New Synthesis of 2-Acetamido-2-deoxy-4-O-β-D-galactopyranosyl-α-D-glucopyranose (N-Acetyllactosamine)

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概要

• 論文の詳細を見る

• A new synthetic route of N-acetyllactosamine is described. This starts from 2-O-tosylate or 2,3'-di-O-tosylate of 1,6-anhydro-4', 6'-O-benzylidene-β-lactose (1), which is the primary or the secondary major product of partial tosylation of compound 1 as reported in Part VIII of this series (T. Takamura and S. Tejima, Chem. Pharm. Bull. (Tokyo), 26,1117 (1978)). The final product is isolated in about 10% yield from compound 1 via the following series of reaction : 1), monoepoxide formation, 2), azidolysis of the epoxide, 3), acetolysis of the azido sugar, 4), reduction of the azido group to amino group, followed by acetylation, and 5), de-O-acetylation.

• 公益社団法人日本薬学会の論文
• 1979-03-25

著者

• 手島 節三

  名古屋市立大学薬学部

• 手島 節三

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 高村 吏

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 千葉 拓

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 手島 節三

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 高村 吏

  Research And Development Division General Laboratory Arakawa Chotaro & Co.

• 千葉 拓

  名古屋市立大学薬学部

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