Promoter function of carrageenan on development of colonic tumors induced by 1,2-dimethylhydrazine in rats.
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概要
- 論文の詳細を見る
In order to understand the function of Carrageenan, an indigestible polysaccharide, as a promoter of colonic tumors induced by 1, 2-dimethylhydrazine (DMH), molecular weight distribution of fecal carrageenan and amounts of fecal bile acids in rats given carrageenan and DMH treatment were examined. Gel filtration pattern on Sephacryl 5-300 of fecal carrageenan was very similar to that of feeding carragee-nan, and carrageenan ingested was quantitatively excreted in feces. Hexafluoroisopropyl ester-trifluoroacetyl derivatives of fecal bile acids were analyzed by gas chromatography on QF-l. Although there was a decreased concentration of deoxycholic acid and total bile acids in carrageenan-fed rats compared to control rats, no difference in the daily output was found because carrageenan ingestion increases fecal output. Significant increased concentration and daily output of lithocholic acid, a tumor-promoter, by feeding carrageenan were found. Thus, it was suggest-ed that the promoting effect of carrageenan on colon tumorigenesis by DMH may be mediated by increased excretion of lithocholic acid and may not participate in degradation of carrageenan ingested.
- 財団法人 学会誌刊行センターの論文
著者
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手島 節三
Faculty Of Pharmaceutical Sciences Nagoya City University
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伊藤 正夫
Division of Biology, Aichi Prefectural Institute of Public Health
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荒川 正一
Division of Biology, Aichi Prefectural Institute of Public Health
関連論文
- Synthesis of 2-Acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-deoxy-3-O-(α-L-fucopyranosyl)-D-glucopyranose (3-O-α-L-Fucopyranosyl-di-N-acetylchitobiose)
- Chemical Modification of Lactose. XIII. Synthesis of Lacto-N-tetraose
- A Preparation of the Branched Trisaccharide 2-Acetamido-2-deoxy-4-O-(β-D-galactopyranosyl)-3-O-(β-D-xylopyranosyl)-D-glucopyranose (3-O-β-D-Xylopyranosyl-N-acetyllactosamine)
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- Synthesis of Methyl O-β-D-Galactopyranosyl-(1→6)-O-α-D-galactopyranosyl-(1→6)-O-α-D-galactopyranosyl-(1→6)-O-β-D-glucopyranoside
- Chemical Modification of Lactose. IX. Synthesis of O-β-D-Galactopyranosyl-(1→6)-O-β-D-galactopyranosyl-(1→4)-D-glucopyranose (6'-Galactosyllactose)
- A Facile Synthetic Approach for Alkyl α-Glycosides of Reducing Disaccharides
- The Lipase-Catalyzed Reaction of n-Alkyl n-Butyrates with Methanol
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- Chemical Modification of Lactose. XIII. Synthesis of Lacto-N-tetraose
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- Chemical Modification of Maltose. V. A New Synthesis of 2-Acetamido-2-deoxy-4-O-α-D-glucopyranosyl-α-D-glucopyranose (N-Acetylmaltosamine)
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- Chemical Modification of Maltose. III. Selective p-Toluenesulfonylation of 1,6-Anhydro-4', 6'-O-benzylidene-β-maltose
- Studies on Catalytic Hydrogenation of the Exocyclic Double Bond in Reducing Disaccharides
- Selective Benzoylation of 1,6-Anhydro-4', 6'-O-benzylidene-β-maltose
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- Thiosugars. VI. Reaction Products of Potassium Alkyl- and Benzylxanthates with Acetylated Glucosyl Halides.
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- Synthesis of 2-Acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-deoxy-6-O-(α-L-fucopyranosyl)-D-glucopyranose (6-O-α-L-Fucopyranosyl-di-N-acetylchitobiose)
- A New Synthesis of 2-Acetamido-4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-1,3,6-tri-O-acetyl-2-deoxy-α-D-glucopyranose (Chitobiose Octaacetate)
- Syntheses of O-α-and O-β-D-Galactopyranosyl-(1→6)-O-[α-D-glucopyranosyl-(1→4)]-D-glucopyranoses
- Synthesis of O-α-and O-β-D-Galactopyranosyl-(1→6)-O-α-D-glucopyranosyl-(1→4)-D-glucopyranoses
- Chemical Modification of Lactose. V. Synthesis of 6'-Acetamido-6'-deoxy-α-lactose
- Chemical Modification of Lactose. IV. Syntheses of Disaccharide Derivatives Predominantly Modified at the C-6 Position in Lactose
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- In Vivo and in Vitro Antitumor Activity of Sugars containing Sulfur
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- Thiosugars. XII. Studies on Unsaturated Sugars derived from Glucosyl N, N-Dimethyldithiocarbamate.
- Thiosugars. XI. Further Studies on Thiolevoglycosans.
- Studies on the Fischer's Glucal-hydrobromid-diacetat and Glucal-hydrobromid-triacetat
- Syntheses of Acetylated Trisaccharides, Manα1→3Manβ1→4GlcNAc and Manα1→2Manβ1→4GlcNAc, relating to Mannosidosis
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- Synthesis of Anomers of 6-O-Tosyl-1,3,4-tri-O-acetyl-N-acetyl-D-glucosamine and 1,6-Anhydro-N-acetyl-β-D-glucosamine.
- A New Synthesis of 1,6-Anhydro-β-D-glucopyranose (Levoglucosan).
- Biochemical Studies on Thiosugars. III. Synthesis of 6-Deoxy-6-mercapto-D-glucose.
- Reaction Products of Glucuronic Acid with Phenylhydrazine.
- Biochemical Studies on Thiosugars. II. Synthesis of N-Acetyl-1-thio-D-glucosamine and its Derivatives.
- Biochemical Studies on Thiosugars. I. Synthesis of 1-Thio-D-glucuronic Acid.
- Syntheses of Acetylated Tetrasaccharides, Manα1→2Manα1→3Manβ1→4GlcNAc and Manα1→3Manα1→6Manβ1→4GlcNAc
- Syntheses of 2-Acetamido-2-deoxy-4-O-β-D-galactopyranosyl-D-glucopyranose (N-Acetyllactosamine) Derivatives
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- Syntheses of 6-Acetamido-6-deoxy-lactose Derivatives
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- Studies on the Bromine Addition Compounds derived from 3,4,6-Tri-O-acetyl-D-glucal
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