動物由来レクチンによる骨髄細胞の腫瘍細胞破壊活性の誘導

概要

論文の詳細を見る
To know the role of animal lectins, we examined their participation in tumor recognition and rejection in cooperation with phagocytic cell cascade. We report here that Sarcophaga peregrina lectin induced in the hemolymph of larvae on injury can lyse MM46 tumor cells in cooperation with bone marrow cells. Carbohydrate moieties on cell membranes were recognized in cytolytic process. We had already reported the inhibition of tumor development in vivo by this lectin. This may be due to a phagocytic cell cascade reaction in which S. peregrina lectin can lyse tumor cells in cooperation with immature bone marrow cells, polymorphonuclear leukocytes and finally with macrophages.
社団法人日本薬学会の論文
1985-02-25