アデニン誘導体ならびに関連化合物47種の抗腫瘍性について
スポンサーリンク
概要
- 論文の詳細を見る
Forty-seven compounds related to adenine derivatives were synthesized and their anti-tumor activity was examined using Ehrlich carcinoma cells. 1-Methyladenosine was found to have some anti-tumor effect on the solid type of Ehrlich carcinoma cells, but no other substances were found to be effective. Correlation between the anti-tumor activity and structure of the tested compounds remains uncertain.
- 社団法人日本薬学会の論文
- 1977-06-25
著者
-
水野 伝一
東京大学薬学部
-
水野 伝一
Faculty Of Pharmaceutical Sciences Teikyo University
-
水野 伝一
帝京大学
-
坂本 恵司
金沢大学薬学部
-
Saito T
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
-
西谷 喬
Faculty of Pharmaceutical Sciences, Kanazawa University
-
西谷 喬
Faculty Of Pharmaceutical Sciences Kanazawa University
関連論文
- 含窒素芳香族複素環化合物84種の抗腫瘍性について
- 癌化学療法剤による, 食細胞の殺癌効果の誘導と増強
- A Rapid and Simple Procedure for Purification of S-II, a Transcription Factor of Ribonucleic Acid Polymerase II(Biological)
- 免疫調節剤による殺細胞因子の血清中への誘導
- 動物由来レクチンによる骨髄細胞の腫瘍細胞破壊活性の誘導
- Taraxacum officinale(セイヨウタンポポ)の熱水抽出物の抗腫瘍性 : 抗腫瘍活性と投与時期の関連について
- Azine系, Guanidine系, Thiourea系, Thiazole系およびTriazoline系化合物の抗腫瘍活性について
- 地衣類中のカチオンおよびアニオン交換樹脂吸着物質, 熱水抽出物, 地衣成分およびその分解産物の抗腫瘍活性について
- Immune Response of Mice in Immunotherapy of Tumors with Syngeneic Antitumor Serum Plus Lipopolysaccharide
- Antitumor Immunity after Surgical Removal of 3-Methylcholanthrene-induced Murine Tumors--Correlation between Resistance and Delayed Hypersensitivity Reaction
- Pyrazolo[3,4-d]pyrimidine誘導体に関する研究(第8報)4-Amino-1-(o-, m-あるいはp-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidineおよびその誘導体の合成と抗腫瘍性について
- 複素環化合物およびKetenethioacetal誘導体を中心とする有機化合物の抗腫瘍性スクリーニング
- Indole誘導体の抗腫瘍性スクリーニング
- アデニン誘導体ならびに関連化合物47種の抗腫瘍性について
- Lactam類, Pyridone類, ならびに関連化合物74種の抗腫瘍性について
- Diketeneより誘導された化合物, ならびに関連化合物の抗腫瘍性スクリーニング
- Passive Immunotherapy of Established Tumor with Syngeneic Antitumor Serum in Combination with Immunopotentiators
- Protective effect of Syngeneic antitumor Serum on Mammary Tumor in a Syngeneic Host
- Antibody-dependent macrophage-mediated cytolysis in a murine syngeneic tumor system
- Co-operation between macrophages and a factor from lymphocytes in tumor lysis in vitro
- 齋藤太郎君を偲んで
- 生化学者から有機合成化学者へ (有機合成化学--多方面へのひろがり) -- (有機合成化学への接点を求める)
- Further Investigation of Antitumor Condurangoglycosides with C-18 Oxygenated Aglycone
- 65 ガガイモ科植物成分の研究 : コンズランゴ皮中の抗腫瘍性配糖体の分離と構造
- Antitumor Active Glycosides from Condurango Cortex
- トランスメンブランコントロ-ルと分子集合 (トランスメンブランコントロ-ル)
- Purines. LXIX. Direct N(1)-Oxidation of 7-Benzyladenine and Stepwise Syntheses of Its N(1)- and N(3)-Oxides
- Purines. LXVII. An Alternative Synthesis of Adenine 7-Oxide : N-Oxidation of the Adenine Ring Utilizing Blocking/Deblocking at the 1-Position
- Purines. LXVI. Adenine 7-Oxide : Its Synthesis, Chemical Properties, and X-ray Molecular Structure
- Purines. LII. Synthesis and Biological Evaluation of 8-Methylguanine 7-Oxide and Its 9-Arylmethyl Derivatives
- Purines. LI. Synthesis and Biological Activity of Hypoxanthine 7-N-Oxide and Related Compounds
- Purines. L. Synthesis and Antileukemic Activity of the Antibiotic Guanine 7-Oxide and Its 9-Substituted Derivatives
- 2-(3-Pyridyl)thiazolidine-4-carboxamide Derivatives. II. Structure-Activity Relationships and Active Configuration of 2-(3-Pyridyl)thiazolidine-4-carboxamides as Platelet-Activating Factor Receptor Antagonists
- Adverse Effect of Antitumor Drugs on the Prevention of Metastasis in Mice
- Screening Test for the Prevention of Metastases produced by Ehrlich Carcinoma Cells
- Synthesis and Biological Activity of the Metabolites of N-[2-(1-Azabicyclo[3.3.0]octan-5-yl)ethyl]-2-nitroaniline Fumarate (SK-946)
- Synthesis of (1-Azabicyclo[3.3.0]octanyl)methyl-Substituted Aromatic Heterocycles and Their Muscarinic Activity
- Laxative and Anti-diarrheal Activity of Polycarbophil in Mice and Rats
- An Improved Synthesis of Butyl 4-[(4-Amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate (AU-224)
- Synthesis and Gastrointestinal Prokinetic Activity of Novel Benzamide Derivatives with Amphoteric Side Chains
- Calcium Polycarbophil, a Water Absorbing Polymer, Increases Bowel Movement and Prevents Sennoside-Induced Diarrhea in Dogs
- Purines. XXI. Synthesis of Adenine 1-Oxides Carrying an Allylic Side Chain at the 9-Position
- Decalcification of Calcium Polycarbophil in Rats
- Structure-Activity Relationship(SAR)Studies on Oxazolidinone Antibacterial Agents.1. Conversion of 5-Substituent on Oxazolidinone
- フリニルアミノ酸,フリニルヘフタイトおよび関連化合物のサイトカイニン活性について(A. 理学)
- Characterization of the Neurochemical Effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) as a Cognition Activator
- Purines. XIX. The Direct N^6-Alkylation of 1-Alkoxy-9-alkyladenines : An Alternative Synthesis of N^6,9-Dialkyladenines
- 含硫糖類の抗腫瘍性
- Purines. XLVI. Preparation of 1-Ethyladenine from Adenosine
- Immunoliposome-Mediated Gene Transfer into Cultured Myotubes
- Examination of Local Anti-inflammatory Activities of New Steroids, Hemisuccinyl Methyl Glycolates
- 学術貢献賞受賞青柳高明氏の業績
- Gastroprokinetic Effect of a New Benzamide Derivative Itopride and Its Action Mechanisms in Conscious Dogs
- Synthesis of 5-(Alkylamino)-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamides : Key Intermediates for the Synthesis of 3-Alkyl-9-β-D-ribofuranosylpurine Derivatives
- Purines. XXXII. : Synthesis and Ring Fission of 3,9-Dialkyladenines
- Purines. XXIX. Syntheses of 9-Alkyl-2-deuterio-N^6-methoxyadenines and 2-Deuterio-N^6,9-dimethyladenine : Tautomerism in 9-Substituted N^6-Alkoxyadenines(Organic,Chemical)
- Purines. XXV. Fission and Reclosure of the Adenine Ring by the Use of Modified Benzyloxy Groups at the 1-Position
- Purines. XXII. Methylation of 1-, 3-, 7-, 9-, and N^6-Methyladenines Bearing a Methoxyl Group at the N^6-Position : A Synthesis of 7,9-Dimethyladenine
- アデニン環の開裂と再閉環
- Purines. XX. Synthesis of 1-Substituted 5-Aminoimidazole-4-carboxamidines and Related Compounds
- Modification by Fluoride, Bromide, Iodide, Thiocyanate and Nitrite Anions of Reaction of a Myeloperoxidase-H_2O_2-Cl^- System with Nucleosides
- Effects of Fluvastatin and Its Major Metabolites on Low-Density Lipoprotein Oxidation and Cholesterol Esterification in Macrophages
- Fluvastatin, an HMG-CoA Reductase Inhibitor, Protects LDL from Oxidative Modification in Hypercholesterolemic Rabbits
- In Vitro Inhibitory Effects of the Optical Isomers and Metabolites of Fluvastatin on Copper Ion-Induced LDL Oxidation
- An in Vitro Study of the Hydroxyl Radical Scavengin Property of Fluvastatin, and HMG-CoA Reductase Inhibitor
- Purines. XIV. Selective Removal of N-Terminal Amino Acids from Peptides by the Use of Purin-6-yl Group at the N-Terminus
- 2-(3-Pyridyl)thiazolidine-4-carboxamide Derivatives. III. Synthesis of Metabolites and Metabolism of 2-(3-Pyridyl)thiazolidine-4-carboxamides YM461 and YM264 as Platelet-Activating Factor (PAF) Receptor Antagonists
- Synthesis of the Selective 5-Hydroxytryptamine 4 (5-HT_4) Receptor Agonist (+)-(S)-2-Chloro-5-methoxy-4-[5-(2-piperidylmethyl)-1,2,4-oxadiazol-3-yl]aniline
- Intramolecular Oxymercuration with Mercuric Triflate
- Pyridine, Pyridone誘導体43種の抗腫瘍性スクリーニング
- Mercuric Triflate-TMU Catalyzed Hydration of Terminal Alkyne to give Methyl Ketone under Mild Conditions
- Purines.XXXIX. : The Crystal Structure of 9-Benzyl-N^6-methoxyadenine
- Purines. XXXI. : An X-Ray Crystallographic Structure Analysis of 3-Methyladenosine p-Toluenesulfonate
- NOVEL SKEELETAL DITERPENOIDS FROM THE JAPANESE LIVERWORT PALLAVICINIA SUBCILIATA
- アデニン環の開裂と再閉環
- Effect of a Novel Non-steroidal Anti-inflammatory Drug (M-5011) on Cytokine Levels in Rats With Monosodium Urate Crystal-Induced Pleurisy
- 制ガン剤の研究(第15報) : 置換Styrylpyridazine N-Oxide類の合成ならびにその制ガン性について
- 29p-PSB-40 核物理研究センターリングサイクロトロンの現状
- オルガネラの形成と調節(「自己組織・自己制御系の統計力学とその周辺」研究会報告,基研研究会報告)
- 含水量測定に関して(1. 綜説)