Purines. XIX. The Direct N^6-Alkylation of 1-Alkoxy-9-alkyladenines : An Alternative Synthesis of N^6,9-Dialkyladenines

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概要

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• 1-Alkoxy-9-alkyladenines (VIIIa, b, c) have been found to undergo alkylation mainly at the N^6-position when treated with alkyl halide in N, N-dimethylacetamide. The structure of the resulting N^6-alkylated derivatives (IXa, b, c) has been established by comparison with authentic IXa (X=I, ClO_4) and by catalytic hydrogenolysis of IXb, c (X=ClO_4) to N^4,9-dialkyladenines (XIb, c). In the case of the benzyl analog (IXc : X=ClO_4), removal of the benzyloxy group at the 1-position has also been effected stepwise through the 1-oxide (Xc).

• 公益社団法人日本薬学会の論文
• 1976-04-25

著者

• 坂本 恵司

  金沢大学薬学部

• 藤井 澄三

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 板谷 泰助

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 坂本 恵司

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 川勝 哲

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 川勝 哲

  Faculty Of Pharmaceutical Sciences Kanazawa University

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