Quinolizidines. XIX. Synthesis of (-)-9-demethyltubulosine

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概要

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• The chiral synthesis of (-)-9-demethyltubulosine [(-)-1] has been achieved for the first time via a "cincholoipon-incorporating route," which started from cincholoipon ethyl ester [(+)-7] and passed through the intermediates (-)-8, (-)-9, (+)-10, and (-t-)-11. As a result, the absolute configuration of the Alangium vitiense alkaloid 9-deniethyltubulosine has been unequivocally established to be that represented by formula (-)-1.

• 公益社団法人日本薬学会の論文
• 1987-06-25

著者

• 藤井 澄三

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 大場 正志

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 大場 正志

  Kanazawa Univ. Ishikawa Jpn

• Ohba M

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 藤井 澄三

  Shinshu Univ. Nagano Jpn

• 畠山 洋

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 畠山 洋

  Faculty Of Pharmaceutical Sciences Kanazawa University

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