Purines. XX. Synthesis of 1-Substituted 5-Aminoimidazole-4-carboxamidines and Related Compounds
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概要
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Several 1-substituted 5-aminoimidazole-4-carboxamidines (5g-j) have been prepared from the corresponding N'-alkoxyamidines (4a-f) by catalytic hydrogenolysis. In the hydrogenolysis of 4a-f using Raney Ni catalyst, addition of one molar equivalent of hydrochloric acid accelerated the reaction to give 5g-j in acceptable yields. The structures of 5g-j have been confirmed by cyclization to 9-substituted adenines (6g-j) and by alkaline hydrolysis to 1-substituted derivatives (7g-j) of 5-aminoimidazole-4-carboxamide (AICA).
- 公益社団法人日本薬学会の論文
- 1978-06-25
著者
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斎藤 徹
Faculty Of Pharmaceutical Sciences Kanazawa University
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藤井 澄三
Faculty Of Pharmaceutical Sciences Kanazawa University
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板谷 泰助
Faculty of Pharmaceutical Sciences, Kanazawa University
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板谷 泰助
金沢大学薬学部
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Saito T
Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.
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川西 充
Faculty of Pharmaceutical Sciences, Kanazawa University
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川西 充
Faculty Of Pharmaceutical Sciences Kanazawa University
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