Purines. XLVI. Preparation of 1-Ethyladenine from Adenosine

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概要

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• A detailed account is given of the synthesis and glycosidec cleavage of 1-ehyladenosine (2b), which established an alternative synthesis of 1-ethyladenine (3b). Ethylation of adenosine (1) with EtI in AcNMe_2 at 35-38℃ for 90h gave 2b・HI in 54% yield. The hydriodide 2b・HI was readily converted into the perchlorate 2b・HClO_4 and into the free nucleoside 2b. Treatment of 2b・HI with 0.5N aqueous HCl at 92-94℃ for 30min or that of 2b・HClO_4 with boiling AcOH for 60min produced the aglycone 3b in good yield. The free base easily formed the hydrochloride 3b・HCl, and the perchlorate 3b・HClO_4 as well.

• 公益社団法人日本薬学会の論文
• 1990-12-25

著者

• 斎藤 徹

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 藤井 澄三

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 板谷 泰助

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 田中 孚美子

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 板谷 泰助

  金沢大学薬学部

• Saito T

  Research And Development Headquarters Hokurikit Seiyaku Co. Ltd.

• 久田 裕美

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 久田 裕美

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 藤井 澄三

  Shinshu Univ. Nagano Jpn

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