Homeostasis as Regulated by Activated Macrophage. VIII. LPSw (a Lipopolysaccharide from Wheat Fluor) Can Regulate Bone Resorption of Chick Embryo

概要

論文の詳細を見る
The effect of LPSw (a lipopolysaccharide from wheat fluor) on the bone resorption of 18-d chick embryonic calvaria was examined in an organ culture following the method of Raisz. Bone was prelabeled in culture medium containing ^<45>Ca and chased in a cold medium. On addition of test smples, labeled calcium was released indicating the grade of bone resorption. LPSw (10-100 ng/ml) stimulated bone resorption, showing an effect comparable to parathyroid hormone (PTH) (1 U/ml). PTH at 1 U/ml decreased the total amount of calcium and phosphorus, while LPSw did not. LPSw is thus assumed to simulate bone resorption more actively than PTH.
社団法人日本薬学会の論文
1992-05-25