Homeostasis as Regulated by Activated Macrophage. VI. Protective Effect of LPSw (a Lipopolysaccharide from Wheat Fluor) against Acute Infection by Toxoplasma gondii in Mice

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An oral administration of partially purified LPSw, a lipopolysaccharide (LPS) from wheat fluor, at a concentraion of 20 ng/ml in drinking water beginning 1 d after infection significantly decreased mouse mortality and prevented animal weight loss in acute infection with Toxoplasma gondii. Whereas 71% (5/7) of mice in a control group that did not receive LPSw died of toxoplasmosis, only 14% (1/7) of mice treated with LPSw died (p<0.05). The administration of LPS purified from Bordetalla pertussis also significantly decreased the mortality of infected mice. LPS from Escherichia coli and synthetic lipid A (LA-15-PP(506)), however, did not show a significant decrease in mortality.
社団法人日本薬学会の論文
1992-05-25