Studies on Pyrimidinylpyrazoles. I. Syntheses of 1-and 2-Pyrimidinyl-3-methylpyrazolin-5-one Derivatives
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概要
- 論文の詳細を見る
In order to find new analgesics and anti-inflammatories, 1-and 2-pyrimidinyl-3-methylpyrazolin-5-one derivatives (III and VII) were synthesized from hydrazinopyrimidines (I) and ethyl acetoacetate or ketene dimer, and then methylated to afford 1-and 2-pyrimidinyl-3-methyl-5-methoxypyrazoles (IV and VIII), 1-pyrimidinyl-2,3-dimethylpyrazolin-5-ones (V), and 2-pyrimidinyl-1,3-dimethylpyrazolin-5-ones (IX). Physical properties of these derivatives were also described.
- 公益社団法人日本薬学会の論文
- 1969-07-25
著者
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吉川 徹
Central Research Laboratory Daiichi Seiyaku Co. Ltd.
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内藤 武男
Central Research Laboratory, Daiichi Seiyaku Co., Ltd.
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内藤 武男
Research Laboratories, Daiichi Seiyaku Co., Ltd.
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内藤 武男
Research Laboratories Daiichi Seiyaku Co. Ltd.
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北原 〓一
Central Research Laboratory, Daiichi Seiyaku Co., Ltd.
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青木 直右門
Central Research Laboratory, Daiichi Seiyaku Co., Ltd.
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青木 直右門
Central Research Laboratory Daiichi Seiyaku Co. Ltd.
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北原 〓一
Central Research Laboratory Daiichi Seiyaku Co. Ltd.
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