Investigations on Steroids. X. Pharmacological Studies. (4). Conversion of 17β-Hydroxy-5α-androstano [2,3-c] furazan into 17-Oxo Compound by Rat Liver in Vitro
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17β-Hydroxy-5α-androstano [2,3-c] furazan (I) was incubated with rat-liver mince in the presence of NAD and nicotinamide in oxygen atmosphere. It has been demonstrated that at least 23% of the steroid (I) is converted into 17-oxo-5α-androstano [2,3-c] furazan. This oxidation rate at the 17-position is the same as that observed for testosterone, indicating the substituted furazan ring has no significantly different effect on the metabolic oxidation at this position. The relation of this fact to myotrophic activity of I by oral route has been discussed.
- 公益社団法人日本薬学会の論文
- 1968-08-25
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関連論文
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