Studies on Nucleosides and Nucleotides. X. Nucleophilic Substitution of Secondary Sulfonyloxy Groups of Pyrimidine Nucleosides. III. Reaction of 2', 3'-Di-O-tosyluridine with Methanolic Ammonia
スポンサーリンク
概要
- 論文の詳細を見る
1-(2', 3'-Epoxy-β-D-lyxofuranosyl) isocytosine (IV) was obtained in the reaction of 2', 3'-di-O-tosyluridine (I) with methanolic ammonia through 2', 2'-anhydro-1-(3'-O-tosyl-β-D-arabinofuranosyl) uracil (II) and 2-O-methyl-1-(2', 3'-epoxy-β-D-lyxofuranosyl)-uracil (III). Ultraviolet absorption spectra of 2-substituted-uracils and their nucleosides were comparatively examined and their pK_a values were determined. From the nuclear magnetic resonance spectra it was found that amino group of isocytosine derivatives was existed as amino form and that H_1' of 2', 3'-epoxylyxosyl nucleosides did not couple with H_2' and its signal appeared as a sharp singlet.
- 公益社団法人日本薬学会の論文
- 1968-03-25
著者
関連論文
- Studies on Nucleosides and Nucleotides. VIII. Nucleophilic Substitution of Secondary Sulfonyloxy Groups of Pyrimidine Nucleosides. (1)
- The Nucleophilic Substitution of Secondary Sulfonyloxy Groups of Pyrimidine Nucleosides
- Studies on Nucleosides and Nucleotides. XII. Syntheses of 3'-Amino-3'-deoxypentofuranosylcytosines
- Studies on Nucleosides and Nucleotides. XI. Nucleophilic Substitution of Secondary Sulfonyloxy Groups of Pyrimidine Nucleosides. IV. Deamination in Isocytosine Derivatives and Dealkoxylation in 2-O-Alkyl-pyrimidine Nucleosides
- Studies on Nucleosides and Nucleotides. X. Nucleophilic Substitution of Secondary Sulfonyloxy Groups of Pyrimidine Nucleosides. III. Reaction of 2', 3'-Di-O-tosyluridine with Methanolic Ammonia
- Studies on Nucleosides and Nucleotides. IX. Nucleophilic Substitution of Secondary Sulfonyloxy Groups of Pyrimidine Nucleosides. II. Reaction of 2,2'-Anhydro-1-(3'-O-tosyl-β-D-arabinofuranosyl) uracil with Sodium Bromide, Sodium Ethanethiol, and Sodium Az
- Studies on Nucleosides and Nucleotides. I. Synthesis of Glycosylthymines from Glycosylureas.