Thermal Dehydration of Nafagrel Hydrochloride Hydrate at Controlled Water Vapor Partial Pressures

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概要

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• Nafagrel hydrochloride exists as both a hemihydrate and monohydrate. Conversion from the hemihydrate to the monohydrate is not reversible, and both hydrates can coexist in stable equilibrium between 23% relative humidity (RH) and 64% RH. In order to clarify the dehydration behavior, the kinetics of the thermal dehydration of the hydrates was studied by means of isothermal gravimetry at atmospheric pressure with a controlled water vapor pressure. This revealed that dehydration did not depend on absolute humidity but on RH. The dehydration of the hemihydrate proceeded by two-dimensional gorwth of the nuclei, A_2,but the mechanism of monohydrate dehydration changed from A_2 to a two-dimensional phase boundary, R_2,with an increase in RH. The dehydration of the monohydrate proceeded by R_2,resulting in the production of the hemihydrate at 6.5% RH or above. These kinetic analyses showed that the monohydrate dehydrated faster than the hemihydrate.

• 1995-10-15

著者

• Hakusui H

  Daiichi Pharmaceutical Co. Ltd. Tokyo Jpn

• 伯水 英夫

  Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.

• 北岡 宏章

  Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.

• 大屋 和美

  Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd.,

• 大屋 和美

  Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.

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