Kinetic Studies of the Hydrolysis and Lactonization of Camptothecin and Its Derivatives, CPT-11 and SN-38,in Aqueous Solution
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概要
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The effect of pH and temperature on the reaction rate of the hydrolysis and lactonization of camptothecin and its derivatives, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) and 7-ethyl-10-hydroxycamptothecin (SN-38), in aqueous solution was studied by high-performance liquid chromatography or two-wavelength spectrophotometry. Hydrolysis and lactonization of each compound progressed according to pH-and temperature-dependent pseudo-first-order kinetics. The ratio of the lactone form of each compound to its hydroxy-acid form was determined mainly by the pH of the solution and was not influenced by temperature. Half-lives of the lactone and hydroxy-acid forms of CPT-11 at 37℃ and pH 7.4 were 13.7 min and 4.25 h, respectively.
- 公益社団法人日本薬学会の論文
- 1994-10-15
著者
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河合 明子
Pharmaceutical Formulation Research Center Tokyo Research & Development Center Daiichi Pharmaceu
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秋元 克哉
Pharmaceutical Formulation Research Center Tokyo Research & Development Center Daiichi Pharmaceu
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大屋 和美
Pharmaceutical Formulation Research Center, Tokyo Research & Development Center, Daiichi Pharmaceuti
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大屋 和美
Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd.,
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大屋 和美
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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- Kinetic Studies of the Hydrolysis and Lactonization of Camptothecin and Its Derivatives, CPT-11 and SN-38,in Aqueous Solution