Syntheses of melatonin and its derivatives

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概要

• 論文の詳細を見る

• Two simple synthetic methods for melatonin are newly developed from tryptamine through intermediates, which are promising lead compounds for drug developing research. Novel chemical reactivities of melatonin in its bromination, lithiation, and acylation are also reported.

• 日本複素環化学研究所の論文

著者

• 長谷川 雅司

  Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.

• Hasegawa M

  Faculty Of Pharmaceutical Sciences Kanazawa University

関連論文

• Synthesis and Pharmacological Activities of Novel Bicyclic Thiazoline Derivatives as Hepatoprotective Agents. II. (7-Alkoxycarbonyl-2,3,5,6-tetrahydropyrrolo[2,1-b]thiazol-3-ylidene)acetamide Derivatives
• Synthesis and Pharmacological Activities of Novel Bicyclic Thiazoline Derivatives as Hepatoprotective Agents. I. 8-Ethoxycarbonyl-5,6-dihydrothiazolo[2,3-c][1,4]thiazine Derivatives
• The Chemistry of Indoles.CIII.^ Simple Syntheses of Serotonin, N-Methylserotonin, Bufotenine, 5-Methoxy-N-methyltryptamine, Bufobutanoic Acid, N-(Indol-3-yl)methyl-5-methoxy-N-methyltryptamine, and Lespedamine Based on 1-Hydroxyindole Chemistry
• The first total synthesis of bufobutanoic acid by two routes based on nucleophilic substitution reaction on indole nucleus
• Novel formations of 6-mesyloxytryptamines and 1-substituted 3a-(4- chlorobutoxy)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indoles in the reaction of nb-substituted 1-hydroxytryptamines with mesyl chloride
• Syntheses of melatonin and its derivatives
• A novel methodology for preparing 5-chloro- and 5-bromotryptamines and tryptophans, and its application to the synthesis of (±)-bromochelonin B
• Preparations of melatonin and 1-hydroxymelatonin, and its novel nucleophilic dimerization to (±)-3a,3a'-bispyrrolo[2,3-b]indoles

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