The first total synthesis of bufobutanoic acid by two routes based on nucleophilic substitution reaction on indole nucleus
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概要
- 論文の詳細を見る
Regioselective nucleophilic substitution reaction of 1- hydroxytryptamines led to establish two novel routes for the first synthesis of bufobutanoic acid. An effective synthesis of 5-benzyloxytryptamine from tryptamine is also reported.
- 日本複素環化学研究所の論文
- 2000-05-01
著者
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KURAUCHI Takashi
Faculty of Pharmaceutical Sciences, Kanazawa University
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NAGAHAMA Yoshiyuki
Faculty of Pharmaceutical Sciences, Kanazawa University
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長谷川 雅司
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Hasegawa M
Faculty Of Pharmaceutical Sciences Kanazawa University
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Kurauchi Takashi
Faculty Of Pharmaceutical Sciences Kanazawa University
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Nagahama Yoshiyuki
Faculty Of Pharmaceutical Sciences Kanazawa University
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- Synthesis and Pharmacological Activities of Novel Bicyclic Thiazoline Derivatives as Hepatoprotective Agents. I. 8-Ethoxycarbonyl-5,6-dihydrothiazolo[2,3-c][1,4]thiazine Derivatives
- The Chemistry of Indoles.CIII.^ Simple Syntheses of Serotonin, N-Methylserotonin, Bufotenine, 5-Methoxy-N-methyltryptamine, Bufobutanoic Acid, N-(Indol-3-yl)methyl-5-methoxy-N-methyltryptamine, and Lespedamine Based on 1-Hydroxyindole Chemistry
- The first total synthesis of bufobutanoic acid by two routes based on nucleophilic substitution reaction on indole nucleus
- Novel formations of 6-mesyloxytryptamines and 1-substituted 3a-(4- chlorobutoxy)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indoles in the reaction of nb-substituted 1-hydroxytryptamines with mesyl chloride
- Syntheses of melatonin and its derivatives
- A novel methodology for preparing 5-chloro- and 5-bromotryptamines and tryptophans, and its application to the synthesis of (±)-bromochelonin B
- Preparations of melatonin and 1-hydroxymelatonin, and its novel nucleophilic dimerization to (±)-3a,3a'-bispyrrolo[2,3-b]indoles