Anti-VEGF Receptor Antagonist (VGA1155) Reduces Infarction in Rat Permanent Focal Brain Ischemia
スポンサーリンク
概要
- 論文の詳細を見る
Background and Purpose: Vascular endothelial growth factor (VEGF) is a majormediator of angiogenesis and a strong vascular permeability factor. VEGF is known toopen the blood-brain barrier (BBB) and induce cerebral edema. Experimental studiesof VEGF antagonism have shown it reduces cerebral edema after ischemia, indicatingits potential for prevention of secondary brain damage. We examined the therapeuticeffect of VGA1155 (5- [N-Methyl-N- (4-octadecyloxyphenyl) acetyl] amino-2-methyl-thiobenzoicacid), a novel small molecule antagonist of VEGF, on rat permanent focalcerebral ischemia.Methods: Permanent middle cerebral artery occlusion (MCAO) was induced withthe suture occlusion method. A single dose of VGA1155 (10mg/kg, i.p.) wasadministered 30 minutes before the induction of MCAO after which brain watercontent, Evans blue extravasation, neurological score, infarct volumes and VEGFexpression determined by means of ELISA were compared with corresponding valuesfor vehicle injected control rats.Results: Brain water content and Evans Blue extravasation 24 hours after ischemiawere not significantly reduced, but, compared with control group, VGA1155significantly reduced infarct volume (32.0% for VGA1155 vs. 46.7% for control; %volume of hemisphere volume) and improved neurological function 7 days afterischemia, when tissue content of the VEGF group markedly increased to nine times thatof the vehicle-treated animals.Conclusion: VGA1155 was found to protect against secondary ischemic braindamage after permanent focal cerebral ischemia, although it did not reduce vasogenicedema at 24 hours. Changes in endogenous VEGF may be related to the therapeuticeffect of VGA1155.
- 神戸大学の論文
著者
-
HOSODA Kohkichi
Department of Neurosurgery, Kobe University Graduate School of Medicine
-
KOHMURA Eiji
Department of Neurosurgery, Kobe University Graduate School of Medicine
-
SASAYAMA Takashi
Department of Neurosurgery, Kobe University Graduate School of Medicine
-
KOYAMA Junji
Department of Neurosurgery, Kobe University Graduate School of Medicine
-
Kondo Takeshi
Department of Cardiology, Takase Clinic
-
Kondo Takeshi
Department Of Cardiology Takase Clinic
-
MIYAKE Shigeru
Department of Neurosurgery, Toyooka Hospital
-
Koyama Junji
Department Of Neurosurgery Kobe University Graduate School Of Medicine
-
Koyama Junji
Department Of Neurosurgery Hyogo Brain And Heart Center At Himeji
-
Sakurai Takashi
神戸大学 医学研究科脳神経外科
-
Kohmura Eiji
神戸大学 医学研究科脳神経外科
-
Chiba Yoshiyuki
Department of Neurosurgery, Kobe University Graduate School of Medicine
-
Kondoh Takeshi
Kobe University Graduate School of Medicine
-
Hosoda Kohkichi
Department Of Neurosurgery Kobe University Graduate School Of Medicine
-
Sasayama Takashi
Department Of Neurosurgery Kobe University Graduate School Of Medicine
-
Miyake Shigeru
Department Of Neurosurgery Kobe University Graduate School Of Medicine
-
Hosoda Kohkichi
Department Of Neurosurgery Hyogo Brain & Heart Center At Himeji
-
Tamaki Masahiro
Department Of Neurosurgery Kobe University Graduate School Of Medicine
-
Kondoh Takeshi
Department Of Neurosurgery Graduate School Of Medicine Kobe University
-
Kohmura Eiji
Department Of Neurosurgery Graduate School Of Medicine Kobe University
-
Chiba Yoshiyuki
Department Of Dermatology Yokohama City University School Of Medicine
-
Kondo Takeshi
Department Of Applied Biological Science Tokyo University Of Agriculture And Technology
関連論文
- Spontaneous Cerebrospinal Fluid Rhinorrhea Associated With a Far Lateral Temporal Encephalocele : Case Report
- Epidermoid Cyst in Meckels Cave With Unusual Computed Tomography and Magnetic Resonance Imaging Findings : —Case Report—
- PJ-124 Diagnostic Accuracy of MDCT and CAG for Decison Making of PCI Strategy to CTO of RCA(PJ021,Coronary Revascularization, PCI (Complex Lesions) (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- The Novel VEGF Receptor Antagonist, VGA1155, Reduces Edema, Decreases Infarct and Improves Neurological Function after Stroke in Rats
- Long-Term Survival After Surgical Resection of Primary Spinal Malignant Melanoma : Case Report
- PE-001 Clinical Significance of Serum Concentrations of High-mobility Group Box 1 (HMGB1) in Patients with Acute Coronary Syndrome(Acute coronary syndrome, basic/clinical-4 (IHD) PE1,Poster Session (English),The 70th Anniversary Annual Scientific Meeting
- ECHOCARDIOGRAPHIC STUDY OF CHANGES IN SIZES OF LEFT VENTRICLE, LEFT ATRIUM AND INFERIOR VENA CAVA DURING SUPINE ERGOMETER EXERCISE IN PATIENTS WITH MITRAL STENOSIS : Hemodynamics, Cardiac Function (IV) : IV : 48 Annual Scientific Meeting, Japanese Circula
- ASSESSMENT OF VENTRICULAR EXCITATION AND CONTRACTION SEQUENCE BY THE USE OF BODY SURFACE POTENTIAL MAPPING AND PHASE IMAGES IN RADIONUCLIDE VENTRICULOGRAPHY : Arrhythmias (II), Electrophysiology (II), Mapping : III : 48 Annual Scientific Meeting, Japanese
- AMPLITUDE ANALYSIS AND COLOR ENCODING OF TWO-DIMENSIONAL ECHOCARDIOGRAMS IN PATIENTS WITH ANTEROSEPTAL MYOCARDIAL INFARCTION AND LEFT VENTRICULAR HYPERTROPHY : Doppler, RI : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- USEFULNESS OF TOMOGRAPHIC PHASE IMAGE IN THE DIAGNOSIS OF VENTRICULAR CONDUTION ABNORMALITIES : Doppler, RI : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- THALLIUM KINETICS BY THALLIUM WHOLE BODY SCINTIGRAPHY IN VARIOUS HEART DISEASES : Doppler, RI : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- STUDY ON SEPTAL Q WAVES IN EXERCISE BODY SURFACE POTENTIAL MAPS: ANGIOGRAPHIC CORRELATION : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Exercise Test
- COMPARISON OF FACTORS AFFECTING THE PROGRESS OF REHABILITATION WITH FACTORS AFFECTING THE MORTALITY IN ACUTE MYOCARDIAL INFARCTION : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Ischemic Heart Disease (III)
- 16) THE ECG, VCG AND BODY SURFACE QRS MAP OF SIMULATED PREEXCITATION
- Exercise Stress Body surface Isopotential Map in Patients with Coronary Artery Disease : Comparison with Coronary Angiographic and Stress Myocardial Perfusion Scintigraphic Findings : CLINICAL APPLICATION OF BODY SURFACE MAPPING
- -0737-NONINVASIVE ASSESSMENT OF EARLY REPERFUSION USING THE SERIAL CHANGE OF SERUM MYOGLOBIN CONCENTRATION
- EVALUATION OF LEFT VENTRICULAR VOLUME AND WALL MOTION BY CINE-MRI : CT, MRI : 53 Annual Scientific Meeting, Japanese Circulation Society
- ASSESSMENT OF VENTRICULAR EXCITATION AND CONTRACTION SEQUENCE BY THE USE OF BODY SURFACE POTENTIAL MAPPING AND PHASE IMAGES IN RADIONUCLIDE VENTRICULOGRAPHY : Arrhythmias (II), Electrophysiology (II), Mapping : III : 48 Annual Scientific Meeting, Japanese
- -1082-DETECTION OF VALVULAR REGURGITATION AND CARDIAC SHUNT BY ECG-GATED FIELD ECHO REPHASING CINE MAGNETIC RESONANCE IMAGING : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -555- INVESTIGATION OF FRACTIONAL DISTRIBUTION OF CARDIAC OUTPUT DURING VARIOUS EXERCISE STRESS TESTING USING THALLIUM-201 WHOLEBODY SCINTIGRAPHY
- Epidermoid Cyst in Meckel's Cave With Unusual Computed Tomography and Magnetic Resonance Imaging Findings : Case Report
- Acute Cerebellar Edema Following Intra-arterial Tissue Plasminogen Activator Thrombolysis for Basilar Artery Occlusion : Case Report
- OJ-270 Vulnerable and Stable Lesions Estimated by Optical Coherence Tomography (OCT), Intracoronary Ultrasound (IVUS), Angioscopy and Quantitative Coronary Angiography (QCA)(Intravascular endoscopy/Intravascular ultrasound-2 (I) OJ45,Oral Presentation (Ja
- Graft-versus-tumor effect after reduced-intensity allogeneic hematopoietic stem cell transplantation in a patient with advanced colon cancer
- Syringomyelia Due to Thoracic Spinal Stenosis With Ossified Ligamentum Flavum : —Case Report—
- Chronologic Changes of Fasudil Hydrochloride and Hydroxyfasudil in Cerebrospinal Fluid of Patients With Aneurysmal Subarachnoid Hemorrhage
- Postoperative Bilateral Meralgia Paresthetica after Spine Surgery : An Overlooked Entity?
- Endovascular Treatment for a Unusually Large Mycotic Aneurysm Manifesting as Intracerebral Hemorrhage : Case Report
- Multiple Cavernous Angiomas of the Cauda Equina : Case Report
- Acquired Lumbar Epidermoid Cyst in an Adult : Case Report
- Brain Metastasis of Undifferentiated Sarcoma and Response to Temozolomide Treatment : Case Report
- Anti-VEGF Receptor Antagonist (VGA1155) Reduces Infarction in Rat Permanent Focal Brain Ischemia
- Loss of CO2-induced Distensibility in Cerebral Arteries with Chronic Hypertension or Vasospasm after Subarachnoid Hemorrhage
- Effect of VEGF Receptor Antagonist (VGA1155) on Brain Edema in the Rat Cold Injury Model
- Isolated Oculomotor Nerve Paresis in Anaplastic Astrocytoma With Exophytic Invasion
- Carotid artery occulusion and collateral circulation in C57black/6J mice detected by synchrotron radiation microangiography
- Improvement of Visual Acuity Caused by Opticochiasmal Astrocytoma After Treatment for Associated Hydrocephalus : Case Report
- Long-term Survival With Non-functioning Pituitary Carcinoma
- New Technique for Decompressive Duraplasty Using Expanded Polytetrafluoroethylene Dura Substitute : Technical Note
- Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle : Case Report
- Glioblastoma Multiforme Associated With Klinefelter Syndrome : Case Report
- Frameless Stereotactic Surgery Using Intraoperative High-Field Magnetic Resonance Imaging
- Knife Blade Penetrating Stab Wound to the Brain : Case Report
- Use of Microvascular Doppler Sonography in Aneurysm Surgery on the Anterior Choroidal Artery
- Evaluation of Cardiac Motion and Function by Cine Magnetic Resonance Imaging : ADVANCES IN IMAGING TECHNIQUES FOR DIAGNOSIS OF CARDIOVASCULAR DISEASES
- -0965-ASSESSMENT OF MYOCARDIAL VIABILITY BY THE EPICARDIAL AND BODY SURFACE MAPPING IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0449-EVALUATION OF SEVERITY OF PATIENTS WITH MYOCARDIAL INFARCTION USING ANAEROBIC THRESHOLD
- Atherosclerotic Plaque Characterization by 0.5-mm-Slice Multislice Computed Tomographic Imaging : Comparison With Intravascular Ultrasound
- PJ-748 Comparison of Atherosclerotic Plaque Characteristics by IVUS and Multislice CT(CT/DSA-9 (I) PJ128,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PE-098 Assessment of Coronary Plaque Volume Measurement Using MSCT on Phantom Study : What Factors Affecting on Measurement?(CT/DSA-3 (I) PE17,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PE-097 Comparison between Fluvastatin and Pitavastatin Ability to Reduce Coronary Artery Plaque Volume Assessed by "Plaque View" Software on MSCT(CT/DSA-3 (I) PE17,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Cir
- OJ-366 Is "10-Year CHD Risk" useful for Prediction of Coronary Artery Plaques on MSCT?(CT/DSA-2 (I) OJ61,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 4 Prediction of Acute Coronary Syndrome by Multislice CT(Prediction of Acute Coronary Syndrome,Symposium 6 (SY6) (IHD),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Applicability of ECG-Gated Multislice Helical CT to Patients With Atrial Fibrillation
- What Factors are related with Coronary Plaque Positions and Tissue Characteristics? (X-ray/CT/MRI/DSA 8 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Detection of Proximal Coronary Artery Stenosis by Contrast-Enhanced Multislice Helical CT
- Relationship between Response to and Production of the Aerial Mycelium-inducing Substances Pamamycin-607 and A-factor(Microbiology & Fermentation Technology)
- Thrombotic microangiopathy after treatment with bortezomib and dexamethasone in a patient with multiple myeloma
- Administration of micafungin as prophylactic antifungal therapy in patients undergoing allogeneic stem cell transplantation
- Acute-Onset Pancytopenia in a Postpartum Lactating Woman
- Donor-Type Myelodysplastic Syndrome with t(2;3) and Monosomy 7 after Allogeneic Peripheral Blood Stem Cell Transplantation and Liver Transplantation in a Patient with Severe-Type Aplastic Anemia
- 0.5mm-Slice Multi-Detector Row Spiral Computed Tomography can Assess of the Stent Patency(X-ray/CT/MRI/DSA 7 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-126 Full Cover Stenting of LMT and LAD Plaque is Better than LAD Only in Ostial LAD Plaque Extended to LMT(PJ021,Coronary Revascularization, PCI (Complex Lesions) (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circul
- OE-156 Comparison between New Labeling Method of MDCT and Virtual Histology of IVUS for Non-Calcified Plaque Analysis(OE27,CT/MRI (Coronary/Vascular) 1 (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-165 Coronary MDCT is Useful for Predicting Slow-flow Phenomenon during Coronary Intervention(OE28,Coronary Revascularization, PCI (Restenosis/Others) 1 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Soc
- FRS-030 Prevalence of Significant Luminal Stenosis and Vulnerable Plaque in Zero Coronary Artery Calcium Score(FRS6,Non-invasive Assessment of Coronary Lesions (I),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circ
- ECG-Edit Function in Multidetector-Row Computed Tomography Coronary Arteriography for Patients With Arrhythmias
- PE-235 Long-term Results of PTA for Superficial Femoral Arteries(Peripheral circulation/Vascular disease(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-043 The relationthip, 10-Year cardiovascular disease risk and Metabolic syndrome with coronary MDCT evidence of coronary artery disease(Atherosclerosis, clinical(03)(IHD),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Ci
- OE-160 Impact of Coronary MDCT on Therapeutic Decision-Making in Coronary Artery Disease(CT/DSA(01)(I),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-661 Relation between Renal Artery Stenosis and Coronary Artery Disease(Kidney/Renal circulation-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-351 Predictors of Angiographic slow-flow Phenomenon Following Percutaneous Coronary intervention : Detailed analysis by Intaravascular Ultrasound Virtual Histology(Intravascular endoscopy/Intravascular ultrasound-5, The 71st Annual Scientific Meeting o
- OE-116 ECG-Edit Function in Reconstruction of ECG-gated Coronary MSCT in Arrhythmia(CT/DSA-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Is Pre-Intervention Intravascular Ultrasound Necessary in Evaluating Target Lesion Calcification in Patients Undergoing Transcatheter Therapy?
- Efficacy and safety of Micafungin in Febrile NeutropenicPatients Treated for Hematological Malignancies
- In vitro induction of resistance to metronidazole, and analysis of mutations in rdxA and frxA genes from Helicobacter pylori isolates
- Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia.
- OJ-128 Role of Optical Coherence Tomography (OCT) and 64-slice Multidetector Computed Tomography (MDCT) in the Assessment of Acute Coronary Syndrome (ACS)(Acute coronary syndrome, basic/clinical-2 (IHD) OJ22,Oral Presentation (Japanese),The 70th Anniversa
- Three-Dimensional Images of Extra-Routine Grafts in CABG by Multidetector Computed Tomography
- Vectorcardiographic Evaluation of Myocardial Infarct Size : Departure Parameters are Superior to Conventional Spatial Parameters
- Total Anomalous Pulmonary Vein Drainage in an Adult Diagnosed by Helical Computed Tomography
- P642 Mismatch of Free Fatty Acid(FFA)Metabolism and Blood Flow in Various Heart Diseases : An Evaluation of Metabolism/Flow Map Derived from TICI-201 and I-123 BMIPP SPECT
- PJ-747 Usefulness of MSCT Coronary Angiography for PCI Strategy(CT/DSA-9 (I) PJ128,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Distal Anterior Inferior Cerebellar Artery Aneurysm Occult on Magnetic Resonance Angiography One Month Prior to Rupture
- Cervical Epidural Hematoma After Snowboarding Injury
- PE-479 Clinical Significance of Serum Concentrations of High-mobility Group Box 1 after Additional Treatment in Chronic Heart Failure(Heart failure, clinical-8 (M) PE80,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanes
- EFFECTS OF MULTISTAGE TREADMILL EXERCISE ON PLASMA HORMONE LIVELS IN NORMAL SUBJECTS : Exercise Cardiology : IIIrd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- VECTORCARDIOGRAPHIC MANIFESTATIONS OF HYPERTROPHIC CARDIOMYOPATHY CORRELATION WITH M-MODE ECHOCARDIOGRAPHIC FINDINGS : THE IV CONFERENCE ON VECTORCARDIOGRAPHY
- OJ-193 Adiponectin as a Diagnostic Marker of Metabolic Syndrome(Diabetes/Obesity/Metabolic syndrome-2 (H) OJ33,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-153 Hypoadiponectinemia May be Associated with Null Genotype for Glutathione S-Transferase Mu-1 (GSTM1) and Smoking Habit in Men(Smoking-1 (H) OJ26,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
- PE-613 Risk Stratification Using a Combination of Cystatin-C and BNP after Additional Treatment in Patients with Chronic Heart Failure(Neurohumoral factors-2 (H) PE108,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese
- FRS-034 Risk Stratification Using a Combination of Cystatin-C and BNP in Patients Hospitalized for Worsening Chronic Heart Failure(Clinical Heart Failure, Diagnosis and Treatment-2 (M) FRS7,Featured Research Session,The 70th Anniversary Annual Scientific
- Brief exposure to hypoxia induces bFGF mRNA and protein and protects rat cortical neurons from prolonged hypoxic stress
- Significance of PQ interval in acquisition of coronary multidetector row computed tomography
- Multiple Intracerebral Arteriovenous Malformations in Deep Structure : Case Report
- Panhypopituitarism Induced by Cholesterol Granuloma in the Sellar Region : Case Report
- Immunohistochemical approach for differential expression of protein kinase C subspecies
- Prevalence of anomalous origin of coronary artery detected by multi-detector computed tomography at one center
- Coronary Computed Tomography Angiography-Based Coronary Risk Stratification in Subjects Presenting With No or Atypical Symptoms
- Morbidity of Stereotactic Biopsy for Intracranial Lesions