Glioblastoma Multiforme Associated With Klinefelter Syndrome : Case Report
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概要
- 論文の詳細を見る
A 54-year-old man with Klinefelter syndrome presented with glioblastoma multiforme manifesting as a 2-week history of motor weakness of the bilateral extremities. Magnetic resonance imaging showed multiple heterogeneously enhanced tumors in the bilateral frontal lobes. Angiography showed no tumor stain or arteriovenous shunt. The tumor was partially removed through a right craniotomy. The histological diagnosis was glioblastoma. Immunohistochemical examination showed no O6-methylguanine-deoxyribonucleic acid methyltransferase protein expression. Postoperative local radiotherapy (60 Gy/30 fractions) combined with temozolomide (75 mg/m2 × 42 days) and interferon-beta (3,000,000 U, 3 times/week) was performed. The patients clinical status rapidly deteriorated during chemoradiotherapy, and he died of tumor progression 3.5 months after the surgery. Postmortem examination revealed widespread glioblastoma infiltrating the basal ganglia and thalamus. Klinefelter syndrome is associated with increased cancer predisposition, especially for male breast cancer and germ cell tumors, but glioma is extremely rare. The abnormal genetic constitution of this patient may have been directly responsible for the poor outcome.
- 社団法人 日本脳神経外科学会の論文
- 2009-11-15
著者
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MIZUKAWA Katsu
Department of Neurosurgery, Kobe University Graduate School of Medicine
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KOHMURA Eiji
Department of Neurosurgery, Kobe University Graduate School of Medicine
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SASAYAMA Takashi
Department of Neurosurgery, Kobe University Graduate School of Medicine
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TANAKA Kazuhiro
Department of Neurosurgery, Kobe University Graduate School of Medicine
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MORI Kiyoshi
Department of Thoracic Diseases, Tochigi Cancer Center
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OHBAYASHI Chiho
Department of Pathology, Kobe University School of Medicine
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Ohbayashi Chiho
Department Of Pathology Kobe University Graduate School Of Medicine
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MIZOWAKI Takashi
Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto Unive
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KITAZAWA Sohei
Department of Pathology, Kobe University Graduate School of Medicine
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Mizukawa Katsu
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Sakurai Takashi
神戸大学 医学研究科脳神経外科
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SAKAGAMI Yoshio
Department of Neurosurgery, Kobe University Graduate School of Medicine
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Ohbayashi Chiho
Department Of Pathology Hyogo Prefectural Kakogawa Hospital
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Sasayama Takashi
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Kitazawa Sohei
Department Of Pathology Kobe University Graduate School Of Medicine
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Kitazawa Sohei
Department Of Bioinformatics Kobe University Graduate School Of Medicine
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Kohmura Eiji
Department Of Neurosurgery Graduate School Of Medicine Kobe University
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Mori Kiyoshi
Department Of Pathology Kobe University Graduate School Of Medicine
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Mori Kiyoshi
Department Of Internal Medicine Juntendo University School Of Medicine
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Mizowaki Takashi
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Sakagami Yoshio
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Tanaka Kazuhiro
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Ohbayashi Chiho
Department Of Pathology Hyogo Cancer Center
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Tanaka Kazuhiro
Department Of Advanced Materials Science And Engineering Faculty Of Engineering Yamaguchi University
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MORI Kiyoshi
Department of Critical Care Medicine, Iwate Medical University
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MIZOWAKI Takashi
Department of Neurosurgery, Kobe University Graduate School of Medicine
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