Impaired response of perforating arteries to hypercapnia in chronic hyperglycemia
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概要
- 論文の詳細を見る
Diabetes mellitus increases the risk of cerebrovascular disease, the effects ofhypercapnia on CBF (cerebral blood flow) and cerebrovascular reactivity duringdiabetes are still inconsistent. Here, we have established a new microangiographictechnique using synchrotron radiation (SPring-8, Japan), which enabled us to visualizerat cerebral vessels with high spatial resolution in real time. The goal of the studypresented here was to identify the effects of chronic hyperglycemia onhypercapnia-induced vascular responses (endothelium-dependent vasodilatation) andnitric oxide (NO) donor- induced vascular responses (endothelium-independent) ofperforating arteries and of the deeply located large cerebral arteries. We found asignificant vasodilatation of rat perforating arteries after hypercapnia with a maximumdiameter of approximately 140% of baseline in normal Wistar rats. Chronichyperglycemia impaired vasodilatation of perforating arteries in genetically diabeticGK rats. SNP (sodium nitroprusside) caused a similar vasodilatation of perforatingvessels in normal and chronic hyperglycemia, indicating that endothelium-dependentvasodilatation of perforating arteries may be specifically impaired in chronichyperglycemia. Possible impairment of endothelium-dependent vasodilatation inperforating vessels during chronic hyperglycemia may cause decreased vascularreserve capacity of perforating artery, resulting in the increased ischemic insults andcerebrovascular diseases in diabetes.
著者
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UMETANI Keiji
Japan Synchrotron Radiation Research Institute
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Kurihara Eiji
神戸大学 医系研究 脳神経外科学
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YAMASAKI Katsuhito
Clinical Genome Informatics Center, School of Genome Science, Kobe University
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YAMASAKI Katsuhito
Japan Synchrotron Radiation Research Institute
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Sakurai Takashi
神戸大学 医学研究科脳神経外科
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Kohmura Eiji
神戸大学 医学研究科脳神経外科
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Kohmura Eiji
Kobe University Graduate School Of Medicine
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Kondoh Takeshi
Kobe University Graduate School of Medicine
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Sakurai Takashi
Kobe University Graduate School of Medicine
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Yokono Koichi
Kobe University Graduate School of Medicine
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Oizumi Ximena-Sayuri
Kobe University Graduate School of Medicine
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Akisaki Taichi
Kobe University Graduate School of Medicine
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Kouta Yoshiyuki
Kobe University Graduate School of Medicine
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Song Xiu
Kobe University Graduate School of Medicine
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Takata Toshihiro
Kobe University Graduate School of Medicine
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Hirano Masatsugu
Japan Synchrotron Radiation Research Institute, SPring-8
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TAKATA Toshihiro
Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine
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Song Xiuzhen
Kobe University Graduate School of Medicine
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Sasayama Takashi
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Yokono Koichi
Kobe Univ. Graduate School Of Medicine Jpn
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Yokono Koichi
Internal And Geriatric Medicine Graduate School Of Medicine Kobe University
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Akisaki Taichi
Department Of Internal And Geriatric Medicine Kobe University Graduate School Of Medicine
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Tamaki Masahiro
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Kondoh Takeshi
Department Of Neurosurgery Graduate School Of Medicine Kobe University
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Hirano Masatsugu
Japan Synchrotron Radiation Research Institute Spring-8
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Yokono Koichi
Division Of Geriatric Medicine Kobe University Hospital
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Takata Toshihiro
Department Of Internal And Geriatric Medicine Kobe University Graduate School Of Medicine
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Yamasaki Katsuhito
Clinical Genome Informatics Center School Of Genome Science Kobe University
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Yamasaki Katsuhito
Japan Synchrotron Radiation Research Institute Spring-8
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Yonezawa Kazuyoshi
Division of Geriatric Medicine, Kobe University Hospital
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