Treatment of Recurrent Craniopharyngiomas
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概要
- 論文の詳細を見る
One of the most common complications of craniopharyngioma treatment isrecurrence. The outcomes of treatment for recurrent tumors with different modalitieswere evaluated. Of the 61 patients treated initially, 24 had recurrence during follow-upperiod (1-29 years, mean 11years). Twenty-two patients underwent a total of 35additional operations for recurrence. With reoperation, total surgical removal wasachieved for four occasions (Group a), subtotal resection was achieved with 31 surgicalprocedures. Nineteen procedures (Group b) were done without radiotherapy and sevenwere followed by radiotherapy (Group c). Seven patients were treated withradiosurgery (Group d) with or without surgical resection. The surgical mortality ratefor Group a was 50% which was higher than for initial operation, while for Group b10.5% and none for Groups c and d. Good functional status was maintained at followupin 50% of survived patients for Group a, 14% for Group b, 57% for Group c and86% for Group d. The 5-year recurrence free survival rate was 50% for Group a, 16%for Group b, 80% for Group c, and 83.3% for Group d. The rate of recurrence freesurvival for Group b was significantly lower than Group c (P = 0.004) and Group d (P = 0.001).The recurrence free survival rates were higher for Groups c and d than for Group b.The mortality and morbidity higher in the Group a. Radiotherapy and radiosurgeryare useful adjuncts for the treatment of recurrence, resulting in a high recurrent-freesurvival rate with better functional outcome.
- 神戸大学の論文
著者
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Kohmura Eiji
Kobe University Graduate School Of Medicine
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Tamaki N
Kobe Univ. Graduate School Of Medicine
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Tamaki Norihiko
Kobe University Graduate School Of Medicine
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Ehara Kazumasa
Kobe University Graduate School Of Medicine
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Barua Kanak
Kobe University Graduate School of Medicine
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Tamaki Norihiko
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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