Carotid artery occulusion and collateral circulation in C57black/6J mice detected by synchrotron radiation microangiography
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概要
- 論文の詳細を見る
Using monochromatic synchrotron radiation, we performed microangiography inC57BL/6J mice and investigated their vasculature after unilateral and bilateral carotidartery occlusion. Bilateral occlusion of the carotid artery was made by a ligation of theleft common carotid artery followed by a ligation of the right internal carotid artery(ICA) two days later (n=12). Five days after the second surgery, angiography wasperformed. Unilateral occlusion was made by clipping the right ICA and thenangiography was performed immediately (n=5). The control mice did not undergo anyocclusion (n=5). We removed the brain of the bilateral occlusion mice afterangiography and examined the infarction area. The cerebral microvessels in all animalswere clearly visualized. In the control mice, the posterior communicating artery (Pcom)was not visualized. In the unilateral occlusion mice, the anastomosis of thepterygopalatine artery (PPA) and the external carotid artery (ECA) were recognized.The PPA is thus considered to play a role in the collateral vessel between the ICA andthe ECA. The Pcom was not visualized. In the bilateral occlusion mice, the Pcom wasobserved either unilateraly (n=5) or bilateraly (n=5). The Pcom supplied blood flow tothe anterior circulation from the vertebrobasilar arteries. The bilateral occlusion micethat had at least one visualized Pcom did not have any infarction. We could successfullyvisualize the cerebral vasculature of normal mice and carotid artery occluded mice inan in vivo study. Microangiography can demonstrate the development of vasculatureand the blood flow dynamics in mice.
- 神戸大学の論文
著者
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KOYAMA Junji
Department of Neurosurgery, Kobe University Graduate School of Medicine
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UMETANI Keiji
Japan Synchrotron Radiation Research Institute
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Koyama Junji
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Sakurai Takashi
神戸大学 医学研究科脳神経外科
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Kohmura Eiji
神戸大学 医学研究科脳神経外科
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Kohmura Eiji
Kobe University Graduate School Of Medicine
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Mizobe Takashi
Kobe University Graduate School of Medicine
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Kidoguchi Keiji
Kobe University Graduate School of Medicine
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Kondoh Takeshi
Kobe University Graduate School of Medicine
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Takaki Masahiro
Kobe University Graduate School of Medicine
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Koyama Junji
Kobe University Graduate School of Medicine
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Kondoh Takashi
Kobe University Graduate School of Medicine
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Sakurai Takashi
Kobe University Graduate School of Medicine
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Yokono Koichi
Kobe University Graduate School of Medicine
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Sasayama Takashi
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Yokono Koichi
Kobe Univ. Graduate School Of Medicine Jpn
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Yokono Koichi
Internal And Geriatric Medicine Graduate School Of Medicine Kobe University
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Takaki Masahiro
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Tamaki Masahiro
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Kondoh Takeshi
Department Of Neurosurgery Graduate School Of Medicine Kobe University
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Yokono Koichi
Division Of Geriatric Medicine Kobe University Hospital
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Yonezawa Kazuyoshi
Division of Geriatric Medicine, Kobe University Hospital
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