Effect of VEGF Receptor Antagonist (VGA1155) on Brain Edema in the Rat Cold Injury Model
スポンサーリンク
概要
- 論文の詳細を見る
Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis anda strong vascular permeability factor. Blockade of VEGF may have a potential to treatbrain edema after brain injury. In the rat cold injury model, the VEGF receptorantagonist VGA1155 significantly reduced the brain water content and the maximumeffect was obtained when given at 30 minutes after injury. This effect was indose-dependent manner and the dose of 25 mg/kg showed the maximum effect. Withthis dose, VGA1155 also significantly reduced vascular permeability. Histologicalevaluation of brain lesion showed no significant reduction of damaged area 1 weekafter injury by VGA1155. The data suggest that VGA1155 may have antiedematouseffect in acute phase after cold injury.
- 神戸大学の論文
著者
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KOHMURA Eiji
Department of Neurosurgery, Kobe University Graduate School of Medicine
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KOYAMA Junji
Department of Neurosurgery, Kobe University Graduate School of Medicine
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Kondoh Takeshi
Department Of Medicine Division Of Cardiology Showa University School Of Medicine
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MIYAKE Shigeru
Department of Neurosurgery, Toyooka Hospital
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Koyama Junji
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Koyama Junji
Department Of Neurosurgery Hyogo Brain And Heart Center At Himeji
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Sakurai Takashi
神戸大学 医学研究科脳神経外科
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Kohmura Eiji
神戸大学 医学研究科脳神経外科
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Sasayama Takeshi
Department of Neurosurgery, Kobe University Graduate School of Medicine
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Sasayama Takashi
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Miyake Shigeru
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Tamaki Masahiro
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Kondoh Takeshi
Department Of Neurosurgery Graduate School Of Medicine Kobe University
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Kohmura Eiji
Department Of Neurosurgery Graduate School Of Medicine Kobe University
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Kondoh Takeshi
Department Of Community Dentistry Matsumoto Dental College
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