In Vivo Gene Transfer into the Periventricular Region by Electroporation
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概要
- 論文の詳細を見る
Gene transfer by electroporation was attempted in the normal rat brain. The reporter gene pEGFP-C1(25 μg/5 μ1)was injected into the striatum of young adult rats and various square electrical impulses were applied uising a pair of electrodes implanted in the striatum. The brains were removed and sliced after 5 days. Histological examination revealed that the high energy impuhes caused extensive tissue damage whereas lower energy impulses(200-400 mJ)resulted in the transfection of more than 300 cells per brain, which were widely distributed in the subependymal region of the lateral ventricle and extended long processes into the striatum.
- 日本脳神経外科学会の論文
- 2000-12-15
著者
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KOKUNAI Takashi
Department of Neurosurgery, Kobe University School of Medicine
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TAMAKI Norihiko
Department of Neurosurgery, Kobe University School of Medicine
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Kondoh Takeshi
Department Of Medicine Division Of Cardiology Showa University School Of Medicine
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Saito Naoaki
Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Japan
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Tamaki Norihiko
Department Of Meurosurgery Kobe University School Of Mridicine
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Tamaki Norihiko
Department Of Neurosurgery Kobe University School Of Medicine Kobe
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MOTOOKA Yasuhiko
Department of Neurosurgery, Kobe University School of Medicine, Kobe
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BHATTACHARJEE Abesh
Department of Neurosurgery, Kobe University School of Medicine, Kobe
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Motooka Yasuhiko
Department Of Neurosurgery Kobe University School Of Medicine Kobe
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Kokunai Takashi
Department Of Neurosurgery Kobe University School Of Medicine
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Saito Naoaki
Laboratory Of Molecular Pharmacology Biosignal Research Center Kobe Univ.
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Bhattacharjee Abesh
Department Of Neurosurgery Kobe University School Of Medicine Kobe
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Kondoh Takeshi
Department Of Neurosurgery Kobe University School Of Medicine Kobe
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Saito Naoaki
Laboratory Of Molecular Phormacology Biosignal Research Center Kobe University Kobe
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Kondoh Takeshi
Department Of Community Dentistry Matsumoto Dental College
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