Radiation-induced Brain Damage in Children : Histological Analysis of Sequential Tissue Changes in 34 Autopsy Cases
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概要
- 論文の詳細を見る
The nature and sequence of the radiation-induced changes in the brain were studied postmortem in 34 children with glioma, 22 of whom underwent central nervous system radiation therapy. Twenty received whole-brain or whole-neuroaxis radiation at a total mean dosage of 4063 cGy. Brain tissue alterations were analyzed histologically by means of various staining methods, including immunohistochemical techniques. The histological features of irradiated brains were compared with those of non-irradiated brains. Microscopic findings included demyelination (seven cases), focal necrosis (six cases), cortical atrophy (four cases), endothelial proliferation (four cases), and telangiectatic vascular proliferation with vascular thickening and oozing of a thick fluid (one case). Such findings were rare in non-irradiated patients. Demyelination was observed earliest in a patient who died 5 months after radiation therapy and was more common after 9 months. Focal necrosis was first observed 9 months post-irradiation but was more advanced and extensive after 1 year. Calcified foci were found only after 60 months. Various vascular changes such as vascular thickening and thrombosis suggested ischemic insult to the brain as a late effect of radiation injury. The results of this study suggest that the immature brain may be more sensitive to radiation than is the adult brain, and that the manifestations of radiation-induced injury depend on the time elapsed after irradiation.
- 日本脳神経外科学会の論文
- 1990-01-15
著者
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KOKUNAI Takashi
Department of Neurosurgery, Kobe University School of Medicine
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Matsumoto Satoshi
Department Of Pathology Nara Medical University
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OI Shizuo
Department of Neurosurgery, Kobe University School of Medicine
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Oi Shizuo
Department Of Neurosurgery Kobe University School Of Medicine
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IJICHI Akihiro
Department of Experiment Radiology Oncology, The University of Texas M. D. Anderson Cancer Center
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Kokunai Takashi
Department Of Neurosurgery Kobe University School Of Medicine
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RAIMONDI Anthony
Department of Neurosurgery, Northwestern University Medical School
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Ijichi Akihiro
Department Of Neurosurgery Kobe University School Of Medicine
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Ijichi Akihiro
Department Of Experiment Radiology Oncology The University Of Texas M. D. Anderson Cancer Center
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Raimondi Anthony
Department Of Neurosurgery Northwestern University Medical School
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Matsumoto Satoshi
Department Of Neurological Surgery Kobe University School Of Medicine
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Matsumoto Satoshi
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Matsumoto Satoshi
Department Of Neurosurgery Kobe University School Of Medicine
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Matsumoto Satoshi
Department Of Agricultural Chemistry University Of Tokyo
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