Photodynamic Therapy of Experimental 9L Gliosarcoma : Cytocidal Effect and Pathohistological Analysis
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概要
- 論文の詳細を見る
The effect of photodynamic therapy (PDT) with a hematoporphyrin derivative (HPD) on tumor cell survival was studied in 9L gliosarcoma rat tumor systems, both in vitro and in vivo. In vitro, the cytocldal effect was dependent on HPD concentration and length of exposure to light. The cell death Fate was 100% with 30 minutes of light exposure following 6 hours of culturing in a medium containing 50 μg/ml of HPD. Male Fischer 344 rats were inoculated with 9L gliosarcoma cells to produce frontoparietal surface brain tumors. An argon laser with a wave length of 514.5 nm was used as the light source. The rats were divided into several groups and received either no treatment (controls) or one of various combinations of treatment: HPD without light irradiation, placebo plus light irradiation, or HPD plus light irradiation. No degenerative changes were observed histopathologically in the control rats or those not given HPD. Necrotic foci were prominent in the groups given HPD, regardless of whether the light was delivered directly to the tumor surface or to the skin just above the tumor. The necrotic change of the tumor cells comprised nuclear pyknosis, homogenation of chromatin, and vascular collapse associated with extravasation, venous congestion, hyalinization of endothelium' and massive hemorrhage. These results demonstrate the cytocidal effect of PDT on experimental glioma and suggest that this approach will have important clinical application in neuro-oncology.
- 日本脳神経外科学会の論文
- 1987-07-15
著者
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Matsumoto Satoshi
Department Of Pathology Nara Medical University
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Okuda Yasuhiro
Department Of Neurosurgery National Kagawa Children's Hospital
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OI Shizuo
Department of Neurosurgery, Kobe University School of Medicine
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Oi Shizuo
Department Of Neurosurgery Kobe University School Of Medicine
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Oi Shizuo
Department Of Neurosurgery National Kagawa Children's Hospital
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Matsumoto Satoshi
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Matsumoto Satoshi
Department Of Neurosurgery Kobe University School Of Medicine
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Matsumoto Satoshi
Department Of Agricultural Chemistry University Of Tokyo
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MATSUMOTO Satoshi
Department of Neurosurgery, Kobe University School of Medicine
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Okuda Yasuhiro
Department of Industrial Chemistry, Faculty of Engineering, Kyoto University
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