Brain Metastasis of Undifferentiated Sarcoma and Response to Temozolomide Treatment : Case Report
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概要
- 論文の詳細を見る
A 33-year-old woman presented with rare brain metastases from undifferentiated high-grade sarcoma manifesting as headache and vomiting. Magnetic resonance (MR) imaging demonstrated multiple tumors in the brain, subcutaneous soft tissue, and mediastinum. The patient underwent surgery, followed by chemotherapy and radiotherapy. The histological diagnosis was undifferentiated high-grade sarcoma. Radiotherapy was effective, but the brain tumors recurred 6 months later. The patient underwent high-dose methotrexate therapy, but showed no response. Promoter hypermethylation in the O6-methylguanine-deoxyribonucleic acid methyltransferase (MGMT) genes was detected and MGMT protein expression was negative in the recurrent tumor, so temozolomide (TMZ) salvage chemotherapy was given, and follow-up MR imaging showed tumor reduction. This case suggests that TMZ may be effective for brain metastasis of undifferentiated sarcoma without MGMT protein expression.
- 社団法人 日本脳神経外科学会の論文
- 2010-08-15
著者
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ARAI Atsushi
Department of Neurosurgery, Kobe University Graduate School of Medicine
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NISHIHARA Masamitsu
Department of Neurosurgery, Kobe University Graduate School of Medicine
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KOHMURA Eiji
Department of Neurosurgery, Kobe University Graduate School of Medicine
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SASAYAMA Takashi
Department of Neurosurgery, Kobe University Graduate School of Medicine
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Nishihara Masamitsu
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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KANOMATA Naoki
Department of Pathology, Kobe University Hospital
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Itoh Tomoo
Department Of Surgical Pathology Hokkaido University Hospital
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Itoh Tomoo
Department Of Pathology Kobe University Graduate School Of Medicine
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Arai Atsushi
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Kanomata Naoki
Department Of Pathology Kawasaki Medical School
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Sakurai Takashi
神戸大学 医学研究科脳神経外科
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Kohmura Eiji
神戸大学 医学研究科脳神経外科
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TANAKA Hirotomo
Department of Neurosurgery, Kobe University Graduate School of Medicine
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KAWAMURA Atsufumi
Department of Neurosurgery, Hyogo Prefectural Kobe Children's Hospital
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Sasayama Takashi
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Tamaki Masahiro
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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Kohmura Eiji
Department Of Neurosurgery Graduate School Of Medicine Kobe University
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Kawamura Atsufumi
Department Of Neurosurgery Hyogo Prefectural Kobe Children's Hospital
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Arai Atsushi
Department Of Neurosurgery Kobe University School Of Medicine
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Itoh Tomoo
Department Of Diagnostic Pathology Kanto Teishin Hospital
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Kanomata Naoki
Department Of Pathology 2 Kawasaki Medical School
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Tanaka Hirotomo
Department Of Neurosurgery Kobe University Graduate School Of Medicine
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