Polymyositis as a Paraneoplastic Syndrome in Cytotoxic Molecule-positive and Epstein-Barr Virus-associated Peripheral T-cell Lymphoma, Not Otherwise Specified
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概要
- 論文の詳細を見る
We encountered a rare case of cytotoxic molecule-positive and Epstein-Barr virus (EBV)-associated peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), which was clinically preceded by polymyositis. A 50-year-old woman with a 4-year history of steroid-refractory polymyositis developed ulcerative skin swelling on her left arm. A diagnosis of cytotoxic molecule (TIA-1)-positive and EBV-associated PTCL-NOS was made on the basis of immunohistochemical and molecular examinations of the biopsied brachial muscle. Combination chemotherapies were ineffective, with a fatal outcome. Reassessment of the biopsy specimens of the muscle taken at the age of 46 years showed that the PTCL was already present, indicating that the polymyositis was likely a paraneoplastic manifestation.
著者
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Ito Kiminari
Department Of Cell Therapy Institute Of Biomedical Research And Innovation
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Maruoka Hayato
Department Of Clinical Laboratory Kobe City Medical Center General Hospital
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Akasaka Hiroshi
Department Of Internal Medicine Ii Sapporo Medical University
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Tsunemine Hiroko
Department Of Hematology And Oncology Kyoto University Hospital
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Itoh Tomoo
Department Of Diagnostic Pathology Kanto Teishin Hospital
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Takahashi Takayuki
Department Of Biophysics And Biochemistry Graduate School Of Science University Of Tokyo
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Kodaka Taiichi
Department of Hematology, Shinko Hospital
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Ishikawa Sakane
Department of Hematology, Shinko Hospital, Japan
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Yamamoto Kazuyo
Department of Hematology, Shinko Hospital, Japan
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Udaka Kengo
Department of Hematology, Shinko Hospital, Japan
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Hiramoto Nobuhiro
Department of Hematology, Shinko Hospital, Japan
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Akasaka Hiroshi
Department of Hematology, Shinko Hospital
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Maruoka Hayato
Department of Laboratory Medicine, Kobe City Medical Center General Hospital, Japan
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