Systemic Follicular Lymphoma with Massive Intestinal Involvement with Leukemic Manifestation
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概要
- 論文の詳細を見る
A 30-year-old man was referred to our hospital with leukocytosis and fecal occult blood. His white blood cell count was 30.2 × 109/L with 79% small- to medium-sized lymphocytes. Surface antigen analysis revealed that these lymphocytes were positive for CD19, CD20, CD10, and CD23, but negative for CD5. The lymphocytes infiltrated the bone marrow. On endoscopic examination of the duodenum and jejunum, many small polypoid lesions were observed. A histologic picture of a biopsied lesion showed diffuse infiltration of small- to medium-sized lymphocytes in the submucosal region. On immunohistochemistry, these lymphocytes were positive for CD20, BCL2, and CD10 (weakly). Polymerase chain reaction analysis of cells from peripheral blood, bone marrow, and intestinal lesion showed a fusion product of BCL2 and immunoglobulin heavy chain (IGH) genes. The fused BCL2/IGH gene was also demonstrated by fluorescence in situ hybridization in the same cell sources. Computed tomography scanning showed marked wall thickening throughout the small intestine and enlarged mesenteric lymph nodes. A diagnosis of follicular lymphoma with massive intestinal involvement in a leukemic state was made. After 6 courses of rituximab-combined CHOP chemotherapy, complete remission was obtained. [J Clin Exp Hematopathol 51(2) : 135-140, 2011]
- 2011-11-01
著者
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Arima Hiroshi
Department of Endocrinology and Diabetes, Field of Internal Medicine, Nagoya University Graduate Sch
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Maeda Akinori
Department Of Hematology And Clinical Immunology Kobe City General Hospital
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Arima Hiroshi
Department Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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TAKIUCHI Yohko
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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Tabata Sumie
Department Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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Takiuchi Yoko
Department Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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Maruoka Hayato
Department Of Clinical Laboratory Kobe City Medical Center General Hospital
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Nagano Seiji
Department Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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Yanagita Sohshi
Department Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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Matsushita Akiko
Department Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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Ono Yuichiro
Department Of Hygiene Nagoya University School Of Medicine
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ISHIKAWA Takayuki
Kyoto University
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Matsushita Akiko
Department Of Bioengineerig Faculty Of Bioscience And Biotechnology Tokyo Institute Of Technology
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Kato Aiko
Department Of Agricultural Chemistry Yamaguchi University
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Tanaka Yasuhiro
Department Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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Aoki Kazunari
Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University
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Takahashi Takayuki
Department Of Biophysics And Biochemistry Graduate School Of Science University Of Tokyo
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Ishikawa Takayuki
Department Of Animal Sciences Nihon University
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Ono Yuichiro
Departments Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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MARUOKA Hayato
Laboratory Medicine, Kobe City Medical Center General Hospital
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IMAI Yukihiro
Clinical Pathology, Kobe City Medical Center General Hospital
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Imai Yukihiro
Clinical Pathology Kobe City Medical Center General Hospital
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Kato Aiko
Departments Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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Takahashi Takayuki
Departments Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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ONO Yuichiro
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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AOKI Kazunari
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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