Therapeutic Effects of Lenalidomide on Hemorrhagic Intestinal Myeloma-associated AL Amyloidosis
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概要
- 論文の詳細を見る
A 74-year-old woman with refractory IgG-κ multiple myeloma developed massive melena caused by hemorrhagic submucosal tumors in the duodenum and middle jejunum. A biopsy revealed the tumor to be marked AL amyloid deposition. Treatment with bortezomib did not improve the melena or the underlying disease. The patient also developed multiple amyloidomas in the bilateral femoral heads, which caused a fracture in the left femoral head. Treatment with lenalidomide, as the final therapeutic option, resolved the intractable melena and improved both the intestinal lesions and myeloma. This case shows that successful treatment of multiple myeloma leads to marked improvement of accompanying AL amyloidosis.
- 社団法人 日本内科学会の論文
著者
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Arima Hiroshi
Department of Endocrinology and Diabetes, Field of Internal Medicine, Nagoya University Graduate Sch
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Mori Minako
Department Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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Tabata Sumie
Department Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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Takiuchi Yoko
Department Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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Nagano Seiji
Department Of Hematology And Clinical Immunology Kobe City Medical Center General Hospital
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IMAI Hiroyuki
Department of Applied Molecular Science Institute for Molecular Science
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Matsushita Akiko
Department Of Bioengineerig Faculty Of Bioscience And Biotechnology Tokyo Institute Of Technology
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Kato Aiko
Department Of Agricultural Chemistry Yamaguchi University
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Takahashi Takayuki
Department Of Biophysics And Biochemistry Graduate School Of Science University Of Tokyo
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Ishikawa Takayuki
Department Of Animal Sciences Nihon University
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YANAGITA Soshi
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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ONO Yuichiro
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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AOKI Kazunari
Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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Arima Hiroshi
Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital, Japan
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Kato Aiko
Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital, Japan
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Takahashi Takayuki
Department of Hematology, Shinko Hospital, Japan
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Ono Yuichiro
Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital, Japan
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Mori Minako
Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital, Japan
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Nagano Seiji
Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital, Japan
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Imai Hiroyuki
Department of Clinical Pathology, Kobe City Medical Center General Hospital, Japan
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