Antitumor Activity of Some Polysaccharides Isolated from an Edible Mushroom, Ningyotake, the Fruiting Body and the Cultured Mycelium of Polyporous confluens
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概要
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Some polysaccharides extracted from ningyotake, the fruiting body of Polyporous confluens, with hot water (100℃, FI), 1% ammonium oxalate solution (100℃, FII), and 5% sodium hydroxide solution (80℃ FIII) in that order. These polysaccharide fractions were further fractionated by ethanol precipitation and gel filtration on the column of Toyopeart HW-65F with 0.3M sodium hydroxide solution. A strong antitumor activity were found in five xyloglucan-protein complexes, FI-2-a, -b, -c ; FII-2-a, and FIII-2-a. Analyses of physico-chemical properties and IR- and NMR-spectra of these active fractions showed that their main components were (1→3)- ; (1→6)-β-D-glucopyranans containing a small amount of xylose residues and 2-3% of protein. A mucilaginous polysaccharide (N-PS) prepared from the liquid cultured mycelial broth of the fungus, consisted of (1→6)- ; (1→3)-β-D-glucopyranan. Antitumor activities were also found in a subfraction that was purified from N-PS by gel filtration. Also, a strong antitmor activity was found in a polyol polysaccharide and in a formolysis product from N-PS.
- 社団法人日本農芸化学会の論文
- 1992-01-23
著者
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Mizuno Takashi
Faculty of Agriculture, Shizuoka University
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Ito Hitoshi
School of Medicine, Mie University
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Ito H
National Agricultural Res. Organization Mie Jpn
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MATSUURA Akira
Amano Pharmaceutical Co., Ltd.
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Ito Hiroyuki
Precision And Intelligence Laboratory Tokyo Institute Of Technology
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SHIMURA Keishiro
School of Medicine, Mie University
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SUMIYA Toshimitsu
Iwade Mushroom Institute
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Ito Hitoshi
The Japan Atomic Energy Research Institute Takasaki Radiation Establishment
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Ito H
Precision And Intelligence Laboratory Tokyo Institute Of Technology
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Ando Motoharu
Faculty Of Agriculture Shizuoka University
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SUGIE Reiko
Faculty of Agriculture, Shizuoka University
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Sugie Reiko
Faculty Of Agriculture Shizuoka University
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Shimura Keishiro
School Of Medicine Mie University
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Matsuura Akira
Amano Pharmaceutical Co. Ltd.
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Mizuno Takashi
Faculty Of Agriculture Shizuoka University
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Ito Hitoshi
School Of Medicine Mie University
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