Antitumor Activity and Some Properties of Water-soluble Polysaccharides from "Himematsutake," the Fruiting Body of Agaricus blazei Murill(Biological Chemistry)

概要

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Polysaccharides extracted from Himematsutake, the fruiting body of Agaricus blazei Murill with hot water were fractionated and purified by ethanol precipitation, ion-exchange chromatography, gel-filtration, affinity chromatography, etc. A total of 17 polysaccharide samples thus obtained were given an antitumor activity test (Sarcoma 180/mice i.p. p.o. method) and traces of their activities through the fractionation and purification processes were found. FI_0-a-β, FA-1-a-α, FA-1-a-β, and FA-2-b-β, were obtained as water soluble polysaccharides fractions having great antitumor activities. Analyses of physico-chemical properties and IR- and NMR-spectra of these active fractions showed that their main components were: FI_0-a-β, (1→6)-; (1→3)-β-glucan; FA-1-a-α, acidic (1→6)-; (1→4)-a-D-glucan; FA-1-a-β, acidic (1→6)-; (1→3)-ac-D-glucan; and FA-2-b-β, acidic RNA-protein complex.
社団法人日本農芸化学会の論文
1990-11-23