Antitumor Activity and Some Properties of Water-insoluble Hetero-glycans from "Himematsutake," the Fruiting Body of Agaricus blazei Murill(Biological Chemistry)
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概要
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After extraction of a hot-water-soluble polysaccharide (FI) from the fruiting bodies of Himematsutake (Agaricus blazei Murill), water-insoluble polysaccharides were obtained by successive extraction with 1% ammonium oxalate solution (FII), 5% sodium hydroxide solution (FIII and FIV), 20% sodium hydroxide solution (FV), and 5% lithium chloride-dimethylacetamide solution (FVI) in that order. These water-insoluble fractions were further fractionated by ethanol precipitation, gel-filtration, etc. Polysaccharides, polysaccharide-protein complexes, and chitin substances thus obtained were assayed for their antitumor activities using the Sarcoma 180/mice i.p., p.o. method. The heteroglycan-protein complexes, FII-a, -b and -c, obtained from FII had weak antitomor activities. A remarkable antitumor activity was found in a glycoprotein, FIII-2-b, fractionated and purified from Fill. The polysaccharide portion of this polysaccharide-protein complex (polysaccharide, 50.2% and protein, 43.3% each on a weight basis) consisted of (1→≫6)-β-D-glucan, and its protein portion was rich in Asx, Glx, Ala, Leu, and Pro. A high antitumor activity was found in a xyloglucan protein complex, FIV-2-b, fractionated and purified from FIV. Antitumor activity was found also in a glucoxylan, FV-2-a, obtained from FV. No significant antitumor activity was found in a chitin substance, FVI.
- 社団法人日本農芸化学会の論文
- 1990-11-23
著者
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Mizuno Takashi
Faculty of Agriculture, Shizuoka University
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Ito Hitoshi
School of Medicine, Mie University
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Ito H
National Agricultural Res. Organization Mie Jpn
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Nakamura T
Nichirei Research Institute
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Ito Hiroyuki
Precision And Intelligence Laboratory Tokyo Institute Of Technology
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Nakamura T
Tokyo National Coll. Technology Tokyo Jpn
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INAGAKI Ryuichi
Faculty of Agriculture, Shizuoka University
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KANAO Tetsuro
Faculty of Agriculture, Shizuoka University
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HAGIWARA Toshihiko
Nichirei Research Institute
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NAKAMURA Takuji
Nichirei Research Institute
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SHIMURA Keishiro
School of Medicine, Mie University
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SUMIYA Toshimitsu
Iwade Mushroom Institute
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ASAKURA Akihiro
Nichizyo Co., Ltd.
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Kanao Tetsuro
Faculty Of Agriculture Shizuoka University
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Asakura Akihiro
Nichijo Co. Ltd.
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Inagaki Ryuichi
Faculty Of Agriculture Shizuoka University
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Ito Hitoshi
The Japan Atomic Energy Research Institute Takasaki Radiation Establishment
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Ito H
Precision And Intelligence Laboratory Tokyo Institute Of Technology
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Shimura Keishiro
School Of Medicine Mie University
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Mizuno Takashi
Faculty Of Agriculture Shizuoka University
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Ito Hitoshi
School Of Medicine Mie University
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