Inhibitory Effect of a Biscoclaurine Alkaloid, Cepharanthin, on Lung Metastasis of Lewis Lung Carcinoma.
スポンサーリンク
概要
- 論文の詳細を見る
The antimetastatic effect of cepharanthin with or without 5-fluorouracil (5-FU) was examined in an experimental model of lung metastasis induced by Lewis lung carcinoma (3LL) in C57BL/6crSlc mice. Injection of cepharanthin i.p. after removal of the implanted primary tumor inhibited the development of lung metastases. Combination therapy with cepharanthin plus 5-FU inhibited significantly the lung metastases. Lung metastases were inhibited by i.v. injection of peritoneal macrophages activated with cepharanthin. Cepharanthin depressed aniline hydroxylase and aminopyrine demethylase activities of the hepatic microsomal drug-metabolizing system in tumor-bearing mice. Moreover, the concentration of 5-FU in the tissues (lung, liver, kidney, spleen and blood) was increased significantly by coadministration of cepharanthin. A possible mechanism of the inhibition of lung metastases by treatment with cepharanthin may be that this drug acts through macrophage activation and depression of the hepatic microsomal drug-metabolizing system. These findings raise the possibility that combination therapy with cepharanthin plus 5-FU may have clinical value in the prevention of cancer metastasis.
- 公益社団法人 日本薬理学会の論文
著者
-
ITO Hiroko
Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku Univers
-
Amano Hideomi
Laboratory Of Marine Biochemistry Faculty Of Bioresources Mie University
-
NODA Hiroyuki
Laboratory of Marine Biochemistry, Faculty of Bioresources, Mie University
-
Noda Hiroyuki
Laboratory Of Marine Biochemistry Faculty Of Bioresources Mie University
-
Ito Hitoshi
Department Of Pharmacology Mie University School Of Medicine
-
Ito Hiroko
Laboratory of Marine Biochemistry, Faculty of Bioresources, Mie University
関連論文
- Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats
- Complete atrioventricular block due to venous stent migration from innominated vein to right ventricle : A case report
- Genetic variation detected with random amplified polymorphic DNA markers among isolates of the red rot disease fungus Pythium porphyrae isolated from Porphyra yezoensis from Korea and Japan
- Thermal stress responses of a sterile mutant of Ulva pertusa (Chlorophyta)
- cDNA cloning of two types of glutamate dehydrogenase from a reproductively sterile mutant of Ulva pertusa (Chlorophyta) grown under different thermal conditions
- Radical Scavenging and Hyaluronidase Inhibitory Activities of Phlorotannins from the Edible Brown Alga Eisenia arborea
- Anti-allergic effects of the brown alga Eisenia arborea on Brown Norway rats
- Effect of a seaweed mixture on serum lipid level and platelet aggregation in rats
- Detection of the red rot disease fungi Pythium spp. by polymerase chain reaction
- Distribution of free L-cysteine and glutathione in seaweeds
- Comparison of electrophoretic patterns of soluble proteins and isozymes of the red rot disease fungus Pythium sp. isolated from Porphyra yezoensis from Korea and Japan
- Comparison of the morphological and physiological features of the red rot disease fungus Pythium sp.isolated from Porphyra yezoensis from Korea and Japan
- Salinity stress responses of a sterile mutant of Ulva pertusa (Ulvales, Chlorophyta)
- Antitumor Effects of (1⇾3)-β-D-Glucan and(1⇾6)-β-D-Glucan Purified from Newly Cultivated Mushroom, Hatakeshimeji : Lyophyllum decastes Sing.
- Antitumor Active Protein-containing Glycans from the Chinese Mushroom Songshan Lingzhi, Ganoderma tsugae Mycelium
- Halogenated Bis(methylthio)tetrathiafulvalenes as a Unique Donor System
- Anti-Allergic Phlorotannins from the Edible Brown Alga, Eisenia Arborea
- Isolation of a New Anti-Allergic Phlorotannin, Phlorofucofuroeckol-B, from an Edible Brown Alga, Eisenia arborea
- Antitumor Activity and Chemical Modification of Polysaccharides from Niohshimeji Mushroom, Tricholma giganteum
- Antitumor-active Heteroglycans from Niohshimeji Mushroom, Tricholoma giganteum
- Antitumor Polysaccharides from a Chinese Mushroom, "Yuhuangmo," the Fruiting Body of Pleurotus citrinopileatus
- Increasing Cluster Size and the Third Correlation Moment f_3
- A Multi-Regge Model with the Threshold Factor for Cluster Production : Two-Component Analysis of Multiplicity Distributions in p-p Collisions at 50-400 GeV/c
- Accumulations of Free L-Cysteine in the Cell Sap of the Green Alga Valonia macrophysa
- STUDIES ON ANTITUMOR POLYSACCHARIDES, ESPECIALLY D-II, FROM MYCELIUM OF CORIOLUS VERSICOLOR
- EFFECTS OF CORIOLAN, AN ANTITUMOR POLYSACCHARIDE, PRODUCED BY CORIOLUS VERSICOLOR IWADE
- Antitumor Active Fucoidan from the Brown Seaweed, Umitoranoo (Sargassum thunbergii)
- Relativistic Effects and the Confining Force in Heavy Quarkonia : Particles and Fields
- The Use of a Monoclonal Antibody for the Detection of Fungal Parasite, Pythium sp., the Causative Organism of Red Rot Disease, in Seawater from Porphyra Cultivation Farms
- Usefulness of Sodium Hydroxide as a Hydrolytic Agent for the Determination of Tryptophan Content in Seaweed Thalli
- Method for Solving the Nambu-Salpeter-Bethe Equation and Its Application to Nucleon-Nucleon Scattering in the ^3P_1 State
- ANTITUMOR ACTIVITY OF BRONCASMA BERNA AGAINST EHRLICH ASCITES TUMOR IN MICE
- SCREENING OF HOST-MEDIATED ANTITUMOR POLYSACCHARIDES BY CROSSED IMMUNOELECTROPHORESIS USING FRESH HUMAN SERUM
- Two-Body Dirac Equation and Its Wave Function at the Origin(Recent Developments in QCD and Hadron Physics)
- Relativistic Quarkonium Model.II : Radiative E1 Transitions : Particles and Fields
- Nonrelativistic Limit of the Renormalized BS Wave Function at the Origin : Particles and Fields
- On the Renormalization Condition of the Relativistic Wave Function at the Origin
- Zero-Energy Bound States of Two Dirac Particles : On the Properties of Eigenvalue Spectra of the O(4) Families
- Ο(4) Symmetry and Relativistic Composite Model
- The Relativisitic Formula for the Leptonic Decay Widths of Vector Mesons and an Estimate of Quark-pair Creation Effect
- Relativistic Quarkonium Model : Mass Level and Lepton Pair Decay
- cDNA cloning and expression analysis of two heat shock protein genes, Hsp90 and Hsp60, from a sterile Ulva pertusa (Ulvales, Chlorophyta)
- Remarks on the Nonrelativistic El-Transition Formulae in the Quarkonium Model
- Relativistic Quarkonium Model with Retardation Effect. I : Mass Level and Lepton-Pair Decay : Particles and Fields
- On Gluonic Corrections to the Mass Spectrum in a Relativistic Charmonium Model
- Wave Function at the Origin in Qq^^- Quarkonium Decays Described by the Dirac Equation
- On Relativistic Corrections to Mass Spectra in Heavy Quarkonia
- Renormalization of the q^^-q-Annihilation Vertex in a Relativistic Quarkonium Model
- Inhibitory Effect of a Biscoclaurine Alkaloid, Cepharanthin, on Lung Metastasis of Lewis Lung Carcinoma.
- Inhibitory Action of a (1.RAR.6)-.BETA.-D-Glucan-Protein Complex (FIII-2-b) Isolated from Agaricus blazei Murill ("Himematsutake") on Meth A Fibrosarcoma-Bearing Mice and Its Antitumor Mechanism.
- Statistics of Composite Systems and Anyons in the Fractional Quantum Hall Effect
- On the Gluonic Correction to Lepton-Pair Decays in a Relativistic Quarkonium Model : Particles and Fields
- Enhancing effect of antitumor polysaccharide from Astragalus or Radix hedysarum on C3 cleavage production of macrophages in mice.