Antitumor Effects of (1⇾3)-β-D-Glucan and(1⇾6)-β-D-Glucan Purified from Newly Cultivated Mushroom, Hatakeshimeji : Lyophyllum decastes Sing.
スポンサーリンク
概要
- 論文の詳細を見る
Eleven polysaccharides were isolated from a hot-water extract of fruiting bodies of Lyophyllum decastes Sing.by ion-exchange chromatography and gel permeation chromatography. Three polysaccarides(IV-1, IV-2, and IV-3) composed mainly of glucose showed marked antitumor activities against Sarcoma 180 and their average molecular weights were 305kDa, 130kDa and 14kDa, respectively. From methylation analyses and ^<13>C-NMR spectra, it was suggested that IV-1 was a(1⇾3)-β-D-glucan-type polysaccharide, IV-3 was a(1⇾6)-β-D-glucan-type polysaccharide, and IV-2 was a(1⇾3, 1⇾6)-β-D-glucan-type polysaccharide or a mixture of both polysaccharides. Increases in the number of peritoneal macrophages and third component of complement(C3)-positive fluorescent cells in mice treated with IV-1 suggested that the inhibitory effect on tumor growth is due to immunological host-mediated mechanisms.
- 社団法人日本生物工学会の論文
- 2000-07-25
著者
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ITO Hitoshi
Department of Radiology, Okitama Public General Hospital
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Hisamatsu Makoto
Faculty of Bioresources, Mie University
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UKAWA Yuuichi
Research Center Eishogen Co., Ltd.
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Hisamatsu Makoto
Faculty Of Bioresources Mie University
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Ukawa Yuuichi
Research Center Eishogen Co. Ltd.
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Ukawa Yuuichi
Research Center Eishogen Co.ltd.:faculty Of Bioresources Mie Univrsity
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Ito Hitoshi
Department Of Physics Faculty Of Science And Technology Kinki University
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Ito Hitoshi
Department Of Pharmacology Mie University School Of Medicine
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