Effect of Helicobacter pylori-mediated inflammation on nonsteroidal anti-inflammatory drugs-induced gastric mucosal injury

スポンサーリンク

概要

• 論文の詳細を見る

• Helicobacter pylori (H. pylori) infection and nonsteroidal anti-inflammatory drugs (NSAIDs) are two major causes of gastric ulceration, but relation between H. pylori infection and use of these drugs in gastric mucosal injury is controversial. Neutrophils have been implicated in the pathogenesis of gastric mucosal damage induced by H. pylori or NSAIDs. H. pylori itself and H. pylori extract induce neutrophil activation, such as superoxide production, expression of adhesion molecule (CD11b/CD18) and transendothelial migration, capillary plugging. Several clinical and experimental studies demonstrated that the degree of H. pylori-induced gastric mucosal injury was closely correlated with the extents of H. pylori infection and of neutrophil infiltration, suggesting implication in extravascular neutrophils for H. pylori-induced gastric mucosal injury. On the other hand, aspirin promotes neutrophil-endothelial adhesive interactions via increasing CD11b/CD18, but not neutrophil migration to extravascular space. In addition, our recent in vivo study suggests that neutrophils adhering to the blood vessels, but not neutrophils migrating to the interstitium, are implicated in aspirin-induced gastric mucosal injury. Recently, we found that administration of aspirin to gerbils three weeks after H. pylori inoculation produced severe gastric mucosal injury via marked infiltration of neutrophils. In this animal model, pretreatment with anti-neutrophil serum, elastase inhibitor or scavengers of reactive oxygen species remarkably inhibited gastric mucosal injury. These results suggest that H. pylori infection potentiates aspirin-induced gastric mucosal injury by mechanisms that include accumulation of activated neutrophils.

• The Keio Journal of Medicineの論文

著者

• YOSHIKAWA Toshikazu

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Yoshikawa Toshikazu

  First Department Internal Medicine Kyoto Prefectural University Of Medicine

• YOSHIDA Norimasa

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Yoshida Norimasa

  First Department Of Internal Medicine Kyoto Prefectural University Of Medicine

関連論文

• ACTH expression in synovium of patients with rheumatoid arthritis and Lewis rats with adjuvant arthritis
• Tea Catechins with a Galloyl Moiety Reduce Body Weight and Fat
• Multifocal Fibrosclerosis : Retroperitoneal Fibrosis Associated with a Suprasellar Tumor and Pachymeningitis
• New Information about gastrointestinal adrenomedullin
• Generation of Reactive Oxygen Species and 8-Hydroxy-2'-deoxyguanosine Formation From Diesel Exhaust Particle Components in L1210 Cells
• Growth Inhibition of A549 Human Lung Adenocarcinoma Cells by L-Canavanine Is Associated with p21/WAF1 Induction
• W-1 Multiple organ failure (Multiorgan toxicity)
• Recent Trends in Functional Food Science and the Industry in Japan
• Effects of Polysaccharide Derived from Black Currant on Relieving Clinical Symptoms of Japanese Cedar Pollinosis: A Randomized Double-Blind, Placebo-Controlled Trial
• Effects of Polysaccharide Derived from Black Currant on Relieving Clinical Symptoms of Japanese Cedar Pollinosis : A Randomized Double-Blind, Placebo-Controlled Trial
• Involvement of Lipid Peroxidation in Free Fatty Acid-Induced Isolated Rat Pancreatic Acinar Cell Injury
• Eight Cases of Gastric Tumors with Calcification
• Effect of Helicobacter pylori-mediated inflammation on nonsteroidal anti-inflammatory drugs-induced gastric mucosal injury
• Defense mechanism of the esophageal mucosa and esophageal inflammation
• S1-5 Oxidative DNA Damage in Life-style Diseases.
• Spin-Trapping Studies on the Reaction of Iron Complexes with Peroxides and the Effects of Water-Soluble Antioxidants.
• Antioxidant Therapy in Digestive Diseases
• Effect of Helicobacter pylori-mediated inflammation on nonsteroidal anti-inflammatory drugs-induced gastric mucosal injury
• Antioxidative Effects of a Processed Grain Food.

もっと見る 閉じる

スポンサーリンク