Vinegar Intake Enhances Flow-Mediated Vasodilatation via Upregulation of Endothelial Nitric Oxide Synthase Activity
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概要
- 論文の詳細を見る
This study examined the effect of acetate on endothelial nitric oxide synthase (eNOS) in human umbilical vein endothelial cells (HUVECs) by immunoblotting assay and the ability of acetic acid to upregulate flow-mediated vasodilatation in humans. In HUVECs, acetate induced a biphasic increase in the phosphorylated form of eNOS. The amount of phosphorylated eNOS was significantly increased by exposure to 200 μmol/l acetate for 20 min (early phase) and for 4 h (late phase). The inhibitors of cAMP-dependent protein kinase (PKA) and AMP-activated protein kinase (AMPK) blocked acetate-induced eNOS phosphorylation in the early and the late phase respectively. Furthermore, in postmenopausal women, maximum forearm blood flow (FBF) in response to shear stress increased in the vinegar (acetic acid) administered group compared to the placebo group. These results suggest that acetic acid-induced eNOS phosphorylation contributes to upregulation of flow-mediated vasodilatation in humans.
- 2010-05-23
著者
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Kaga Takayuki
Central Research Institute, Mitsukan Group Corporation
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MUROHARA Toyoaki
Department of Cardiology, Nagoya University Graduate School of Medicine
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Kitakaze Masafumi
Cardiovascular Div. Of Medicine National Cardiovascular Center
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Murakami Ryuichiro
Department of Cardiology, Nagoya University Graduate School of Medicine
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Muramatsu Takashi
名古屋大学 循環器内科学
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Kajimoto Yoshitaka
Soiken Incorporation
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Kishi Mikiya
Central Res. Inst. Mizkan Group Corp.
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Kishi Mikiya
Central Research Institute Mizkan Group Corporation
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Fushimi Takashi
Central Research Institute, Mizkan Group Corporation
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Kitakaze Masafumi
Cardiovascular Division Of Medicine National Cardiovascular Center
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Murohara Toyoaki
Department Of Cardiology Nagoya University Graduate School Of Medicaine
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Kaga Takayuki
Central Research Institute Mizkan Group Corporation
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Kaga Takayuki
Central Research Institute Mitsukan Group Corporation
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Murakami Ryuichiro
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Kajimoto Yoshitaka
Soiken Inc. Osaka Prefecture Jpn
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Fushimi Takashi
Central Research Institute Mizkan Group Corporation
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Fushimi Takashi
Central Research Institute Mitsukan Group Corporation
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Takahashi Mikio
Central Research Institute Mizkan Group Corporation
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SAKAKIBARA Syoji
Central Research Institute, Mizkan Group Corporation
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Murohara Toyoaki
Department Of Cardiology Nagoya Graduate School Of Medicine
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Sakakibara Syoji
Central Research Institute Mizkan Group Corporation
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