Oral Administration of Synthetic Retinoid Am80 (Tamibarotene) Decreases Brain β-Amyloid Peptides in APP23 Mice
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概要
- 論文の詳細を見る
The purpose of this study is to investigate whether a synthetic retinoid Am80 (tamibarotene) exhibits any improving effects on amyloid precursor protein (APP)23 mice, a model of Alzheimers disease. Am80 was orally administered in feed to 20-week (5-month)-old APP23 mice at a dose of 0 (control) or 0.5 mg/kg/d for 14 weeks. The Am80 treatment reduced significantly the insoluble Aβ levels in brain, in particular Aβ42, while it gave no apparent effects on the soluble Aβ levels. The results suggest that oral administration of Am80 may have potency to reduce the extracellular Aβ42 of insoluble and possibly oligomeric or protofibril forms, which are related to the cause and/or progression of Alzheimers disease. The Am80 treatment showed no significant effect on spatial learning and memory of APP23 mice by Morris water maze analysis. The main reason for the absence of significance seems based on the large deviation and some mice both in the treated and the non-treated groups would neither swim nor make efforts to reach the platform.
著者
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SHUDO Koichi
Research Foundation Itsuu Laboratory
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Nakayama Hitoshi
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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Kuniyasu Akihiko
Department Of Biofunctional Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University
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Maeda Akira
Department Of Artificial Environment And Systems Yokohama National University
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OHTSUKA Hideyuki
Department of Metallurgy, The University of Tokyo
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KAWAHARA Kohichi
Department of Molecular Cell Function, Graduate School of Medical and Pharmaceutical Sciences, Kumam
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Nishi Kentaro
Department of Molecular Cell Function, Graduate School of Medical and Pharmaceutical Sciences, Kumam
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Suenobu Michita
Department of Molecular Cell Function, Graduate School of Medical and Pharmaceutical Sciences, Kumam
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Nagatomo Kenichiro
Department of Molecular Cell Function, Graduate School of Medical and Pharmaceutical Sciences, Kumam
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Staufenbiel Matthias
Nervous System Department, Novartis Institutes of BioMedical Research Basel
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Nakagomi Madoka
Research Foundation Itsuu Laboratory
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Ohtsuka Hideyuki
Department Of Metallurgy The University Of Tokyo
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Nakayama Hitoshi
Department of Molecular Cell Function, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University
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Nagatomo Kenichiro
Department of Molecular Cell Function, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University
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Nishi Kentaro
Department of Molecular Cell Function, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University
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