Medicinal Foodstuffs. XX. Vasorelaxant Active Constituents from the Roots of Angelica furcijuga KITAGAWA : Structures of Hyuganins A, B, C, and D
スポンサーリンク
概要
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From the methanolic extract with vasorelaxant activity obtained from Angelica furcijuga KITAGAWA, four new khellactone-type coumarins, hyuganins A, B, C, and D, were isolated together with twelve known coumarins, two known acetylenic compounds, and a known lignan. The structures of hyuganins A, B, C, and D were determined on the basis of chemical and physicochemical evidence. Nine principal coumarins (hyuganin A, anomalin, pteryxin, isopteryxin, isoepoxypteryxin, praerosides II and IV, apiosylskimmin, (R)-peucedanol 7-O-β-D-glucopyranoside), two acetylenic compounds [(-)-falcarnol and falcarindiol], and related compounds were examined for inhibitory activities on high concentration of K^+ (High K^+)- and dl-norepinephrine (NE)-induced contractions. The results indicate that the 3'-and 4'-acyl groups of khellactone-type coumarins are essential for the inhibitory activity on the contractions by High K^+. Hyuganin A and anomalin showed inhibitory effects on High K^+-induced contraction, but not on NE-induced contraction. Other active coumarins (pteryxin, isopteryxin, isoepoxypteryxin) and an acetylenic compound (falcarindiol) non-selectively inhibited both contractions by High K^+ and NE.
- 公益社団法人日本薬学会の論文
- 2000-10-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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村上 敏之
京都薬科大学生薬学教室
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村上 孝之
Taiho Pharmaceutical Co. Ltd.
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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NISHIDA Norihisa
Kyoto Pharmaceutical University
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KAGEURA Tadashi
Kyoto Pharmaceutical University
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Murakami Takayuki
Taiho Pharmaceutical Co. Ltd.
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Kageura Tadashi
Department Of Pathological Biochemistry Kyoto Pharmceutical University
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Nishida N
Kyoto Pharmaceutical University
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Nishida N
Kyoto Pharmaceutical Univ. Kyoto Jpn
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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