Bioactive Saponins and Glycosides. XVII. Inhibitory Effect on Gastric Emptying and Accelerating Effect on Gastrointestinal Transit of Tea Saponins : Structures of Assamsaponins F, G, H, I, and J from the Seeds and Leaves of the Tea Plant
スポンサーリンク
概要
- 論文の詳細を見る
Following the investigation of assamsaponins A, B, C, D, and E, four new saponins termed assamsaponins F, G, H, and I were isolated from the seeds of the tea plant (Cammellia sinensis L. var. assamica PIERRE), while assamsaponin J was isolated from its leaves. The structures of assamsaponins F-J were elucidated on the basis of chemical and physicochemical evidence and found to be 16,22-O-diacetyl-21-O-angeloyltheasapogenol E 3-O-[β-D-galactopyranosyl(1→2)][β-D-glucopyranosyl(1→2)-α-L-arabinopyranosyl(1→3)]-β-D-glucopyranosiduronic acid, 21-O-angeloyl-22-O-acetyltheasapogenol E 3-O-[β-D-galactopyranosyl(1→2)][β-D-glucopyranosyl(1→2)-α-L-arabinopyranosyl(1→3)]-β-D-glucopyranosiduronic acid, 21-O-angeloyl-28-O-acetyltheasapogenol E 3-O-[β-D-galactopyranosyl(1→2)][β-D-glucopyranosyl(1→2)-α-L-arabinopyranosyl(1→3)]-β-D-glucopyranosiduronic acid, 21-O-tigloyl-28-O-acetyltheasapogenol E 3-O-[β-D-galactopyranosyl(1→2)][β-D-glucopyranosyl(1→2)-α-L-arabinopyranosyl(1→3)]-β-D-glucopyranosiduronic acid, and 16,21-O-biacetyl-22-O-cinnamoyltheasapogenol B 3-O-[β-D-galactopyranosyl(1→2)][β-D-rhamnopyranosyl(1→2)-α-L-arabinopyranosyl(1→3)-β-D-glucopyranosiduronic acid, respectively.The saponin mixture from the seeds of the tea plant was found to exhibit an inhibitory effect no gastric emptying and an accelerating effect on gastrointestinal transit in mice. Theasaponin E_1,the principle saponin of the tea plant, showed potent activity, while theasaponin E_2 showed none, so that the position of the acyl groups in the sapogenin moiety is important from a pharmacological point of view.
- 公益社団法人日本薬学会の論文
- 2000-11-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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村上 敏之
京都薬科大学生薬学教室
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村上 孝之
Taiho Pharmaceutical Co. Ltd.
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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KAGEURA Tadashi
Kyoto Pharmaceutical University
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Murakami Takayuki
Taiho Pharmaceutical Co. Ltd.
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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Kageura Tadashi
Department Of Pathological Biochemistry Kyoto Pharmceutical University
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Nakamura Junko
Kyoto Pharmaceutical University
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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