A Case of Cortisol Producing Adrenal Adenoma Associated with a Latent Aldosteronoma: Usefulness of the ACTH Loading Test for the Detection of Covert Aldosteronism in Overt Cushing Syndrome
スポンサーリンク
概要
- 論文の詳細を見る
A 36-year-old woman with Cushing syndrome was evaluated for coexisting hyperaldosteronism, which was suggested by an abnormal response of the aldosterone-to-cortisol ratio in peripheral blood to the ACTH-administration despite a low basal aldosterone-to-renin ratio. Computed tomography revealed two independent tumors in the left adrenal gland, and adrenal venous sampling indicated hyperaldosteronism in addition to hypercortisolism in the same side. Postsurgical study including immunohistochemical analysis of steroidogenic enzymes suggested one adenoma to be cortisol-producing and the other, aldosterone-producing. The comorbidity of these different hormone-producing adenomas is not rare and careful pre-surgical evaluation is necessary to avoid post-surgical exacerbation of latent hyperaldosteronism.
著者
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Sasano Hironobu
Department Of Anatomic Pathology Tohoku University School Of Medicine
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Yamashita Yasuyuki
Department Of Diagnostic Imaging Faculty Of Medical And Pharmaceutical Sciences Kumamoto University
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Eto Masatoshi
Department Of Surgery/division Of Surgical Oncology University Of Pittsburgh School Of Medicine
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Shimoda Seiya
Department Of Metabolic Medicine Graduate School Of Medical Sciences Kumamoto University
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Araki Eiichi
Department Of Metabolic Medicine Faculty Of Life Sciences Kumamoto University
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Miyamura Nobuhiro
Department Of Metabolic Medicine Faculty Of Life Sciences Kumamoto University
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Nishi Kazuhiko
Department of Material Science and Chemical Engineering, Yokohama National University
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Araki Eiichi
Department of Metabolic Medicine, Kumamoto University School of Medicine, Japan
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Nishi Kazuhiko
Department of Urology, Faculty of Life Sciences, Kumamoto University, Japan
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Kukidome Daisuke
Department of Metabolic Medicine, Kumamoto University School of Medicine, Japan
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Sakakida Kourin
Department of Metabolic Medicine, Kumamoto University School of Medicine, Japan
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Shigematu Yoshinori
Department of Diagnostic Imaging, Faculty of Life Sciences, Kumamoto University, Japan
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Sasano Hironobu
Department of Pathology, Tohoku University School of Medicine, Japan
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Yamashita Yasuyuki
Department of Diagnostic Imaging, Faculty of Life Sciences, Kumamoto University, Japan
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