Inhibition of Phosphorolytic Degradation of 5-Fluoro-2'-deoxyuridine by Pyrimidine Acyclonucleosides and Normal Pyrimidine Metabolites in Rat and Beagle Tissue Homogenates
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概要
- 論文の詳細を見る
Inhibition constants (K_i) of pyrimidine acyclonucleosides and several normal pyrimidine metabolites for the phosphorolytic degradation of 5-fluoro-2'-deoxyuridine (FUdR) in rat and beagle tissue homogenates (liver and small intestine) were measured. Acyclothymidine (AcycTdR) showed the lowest K_i value for all the homogenates. The K_i/K_m values of AcycTdR and acyclouridine (AcycUdR) depended on the homogenates, and the values (K_i/K_m) in the rat liver homogenate were higher than those in all other homogenates.
- 公益社団法人日本薬学会の論文
- 1988-05-25
著者
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実吉 峯郎
帝京科学大学バイオサイエンス学科
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川口 健夫
Bio-Medical Research Institute, Teijin Limited
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川口 健夫
Faculty Of Pharmaceutical Sciences Josai University
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実吉 峯郎
Japan and Faculty of Pharmaceutical Sciences, Hokkaido University
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