Studies on Antiatherosclerotic Agents. VIII. Synthesis and Structure-Activity Relationship of 4-Hydroxymethyl-1(2H)-phthalazinone Derivatives
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概要
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4-Hydroxymethyl-1(2H)-phthalazinone derivatives were synthesized and assayed for their inhibitory effects on platelet aggregation and edematous arterial reaction. Among the tested compounds, 7-ethoxycarbonyl-4-hydroxymethyl-1(2H)-phthalazinone showed the highest potency in these pharmacological tests. The structure-activity relationship of phthalazinone derivatives and related compounds is discussed.
- 社団法人日本薬学会の論文
- 1980-09-25
著者
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江口 征夫
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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江口 征夫
日本動脈硬化研究所
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石川 正幸
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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杉本 昭子
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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