Studies on Antiatherosclerotic Agents. IX. Synthesis of 7-Ethoxycarbonyl-4-hydroxymethyl-6,8-dimethyl-1(2H)-phthalazinone (EG 626)
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概要
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To enhance the biostability of the ester linkage of 7-ethoxycarbonyl-4-hydroxymethyl-1(2H)-phthalazinone, which has potent biological activities, the corresponding tert-butyl ester (1e) and 7-ethoxycarbonyl-4-hydroxymethyl-6,8-dimethyl-1(2H)-phthalazinone (EG 626) (6) were prepared. The synthesis and inhibitory effects on platelet aggregation and edematous arterial reaction of these and other closely related compounds were investigated. EG 626 appears to be a potentially effective antithrombotic and antiatherosclerotic agent.
- 社団法人日本薬学会の論文
- 1980-09-25
著者
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江口 征夫
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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江口 征夫
日本動脈硬化研究所
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石川 正幸
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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杉本 昭子
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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