Clinical Study Concerning the Relationship between Community-Acquired Pneumonia and Viral Infection in Northern Thailand
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概要
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Objective The etiological agents associated with community-acquired pneumonia (CAP) in Thailand have been studied extensively in bacterial pathogens, but not in viral pathogens. To clarify the association of viral pathogens with CAP, we conducted a comprehensive study of viral and bacterial pathogens in patients with CAP. Methods We enrolled 119 hospitalized patients with CAP in Nakornping Hospital, Chiang Mai, Thailand between 2006 and 2008. The severity of pneumonia was classified and the risk factors for death were estimated. Bacterial and fungal pathogens were determined from specimens taken from blood and sputum, and viral pathogens were identified from nasopharyngeal specimens by RT-PCR using primers specific for 7 respiratory viruses. Results Overall, 29 patients were HIV-infected and 90 patients were non-HIV-infected. The microbial pathogens most commonly isolated among HIV-infected patients were: 4 Klebsiella pneumoniae, 4 Mycobacterium tuberculosis and 3 Haemophilus influenzae. Among non-HIV infected patients, predominant microbial pathogens were: 6 Pseudomonas aeruginosa, 5 Haemophilus influenzae and 4 Klebsiella pneumoniae. As for viral pathogens for CAP, influenza virus was identified from 2 HIV-infected patients and 5 non-HIV infected patients. In addition, human rhinovirus (HRV) and respiratory syncytial virus (RSV) were identified from 2 patients each among non-HIV-infected patients. Conclusion Our study demonstrates that the most common viral agent was influenza virus (5%), followed by HRV (2%) and RSV (2%) among CAP patients in northern Thailand. The underlying chronic obstructive pulmonary disease (COPD) seems to be correlated with the severity of illness.
著者
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SANCHAI Tippaya
Nakornping Hospital
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THARAVICHITKUL Prasit
Department of Microbiology, Faculty of Medicine, Chiang Mai University
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Imamura Yoshihiro
Division Of Cardiology Matsuyama Red Cross Hospital
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Gotoh Kenji
Division Of Infectious Diseases Department Of Infectious Medicine Kurume University School Of Medici
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Yahara Koji
Division Of Biostatistics Kurume University School Of Medicine
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Maneekarn Niwat
Department Of Microbiology Chiang Mai University
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Sirisanthana Thira
Research Institute For Health Sciences
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Watanabe Hiroshi
Division Of Cardiology Hemotology And Endocrinology Niigata University Graduate School Of Medical And Dental Science
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Imamura Yoshihiro
Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan
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Khantawa Banyong
Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University, Thailand
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Hara Koyu
Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan
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Nakazono Yoko
Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan
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Kashiwagi Takahito
Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan
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Hamada Nobuyuki
Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan
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Khositsakulchai Weerayut
Nakornping Hospital, Thailand
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Gotoh Kenji
Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan
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Maneekarn Niwat
Department of Microbiology, Faculty of Medicine, Chiang Mai University, Thailand
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Sirisanthana Thira
Research Institute for Health Sciences, Chiang Mai University, Thailand
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